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A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation.

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Title: A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation.
Authors: Zhang X, Wong W, Cho HS, Yang D, Dixon G, Luo R, Liu D, Torre D, Umeda S, González F, Askan G, Yavas A, Damodaran JR, Rickert RW, Kappagantula R, Pan FC, Aveson VG, Grimont A, Pulecio J, Kaplan SJ, Pan H, Leach SD, Iacobuzio-Donahue CA, Chandwani R, Leslie CS, Huangfu D
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 11. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41959451
AccessLevel: 2
PubType: Academic Journal
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  Data: A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Mar 11. <i>Date of Electronic Publication: </i>2026 Mar 11.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Mar 11
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