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Effects of combined Mediterranean diet and physical activity intervention on the gut microbiome and disease progression in individuals with Parkinson's disease: study protocol for a multicenter, randomized controlled pilot study (PRIME study).

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Title: Effects of combined Mediterranean diet and physical activity intervention on the gut microbiome and disease progression in individuals with Parkinson's disease: study protocol for a multicenter, randomized controlled pilot study (PRIME study).
Authors: Fognani A; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., Rotondo R; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Cassino, Italy., Savo Sardaro ML; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; Department of Anthropology, Northwestern University, Evanston, IL, United States., de Iure A; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., Gaglione M; IRCCS San Raffaele Roma, Cassino, Italy., Casali M; IRCCS San Raffaele Roma, Rome, Italy., Leonardi L; IRCCS San Raffaele Roma, Cassino, Italy., Radicati FG; IRCCS San Raffaele Roma, Rome, Italy., Vacca L; IRCCS San Raffaele Roma, Rome, Italy., Guescini M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Zeppa SD; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Gatta L; Scientific Direction, IRCCS San Raffaele Roma, Rome, Italy., Stocchi F; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., Picconi B; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., De Pandis MF; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Cassino, Italy.
Source: Frontiers in aging neuroscience [Front Aging Neurosci] 2026 Mar 25; Vol. 18, pp. 1743490. Date of Electronic Publication: 2026 Mar 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fognani+A%22">Fognani A</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rotondo+R%22">Rotondo R</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Cassino, Italy.<br /><searchLink fieldCode="AU" term="%22Savo+Sardaro+ML%22">Savo Sardaro ML</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; Department of Anthropology, Northwestern University, Evanston, IL, United States.<br /><searchLink fieldCode="AU" term="%22de+Iure+A%22">de Iure A</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gaglione+M%22">Gaglione M</searchLink>; IRCCS San Raffaele Roma, Cassino, Italy.<br /><searchLink fieldCode="AU" term="%22Casali+M%22">Casali M</searchLink>; IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Leonardi+L%22">Leonardi L</searchLink>; IRCCS San Raffaele Roma, Cassino, Italy.<br /><searchLink fieldCode="AU" term="%22Radicati+FG%22">Radicati FG</searchLink>; IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vacca+L%22">Vacca L</searchLink>; IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Guescini+M%22">Guescini M</searchLink>; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Zeppa+SD%22">Zeppa SD</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Gatta+L%22">Gatta L</searchLink>; Scientific Direction, IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Stocchi+F%22">Stocchi F</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Picconi+B%22">Picconi B</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Pandis+MF%22">De Pandis MF</searchLink>; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Cassino, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101525824%22">Frontiers in aging neuroscience</searchLink> [Front Aging Neurosci] 2026 Mar 25; Vol. 18, pp. 1743490. <i>Date of Electronic Publication: </i>2026 Mar 25 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101525824 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-4365 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216634365%22">16634365 </searchLink><i>NLM ISO Abbreviation: </i>Front Aging Neurosci <i>Subsets: </i>PubMed not MEDLINE
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