Effects of combined Mediterranean diet and physical activity intervention on the gut microbiome and disease progression in individuals with Parkinson's disease: study protocol for a multicenter, randomized controlled pilot study (PRIME study).
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| Title: | Effects of combined Mediterranean diet and physical activity intervention on the gut microbiome and disease progression in individuals with Parkinson's disease: study protocol for a multicenter, randomized controlled pilot study (PRIME study). |
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| Authors: | Fognani A; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., Rotondo R; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Cassino, Italy., Savo Sardaro ML; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; Department of Anthropology, Northwestern University, Evanston, IL, United States., de Iure A; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., Gaglione M; IRCCS San Raffaele Roma, Cassino, Italy., Casali M; IRCCS San Raffaele Roma, Rome, Italy., Leonardi L; IRCCS San Raffaele Roma, Cassino, Italy., Radicati FG; IRCCS San Raffaele Roma, Rome, Italy., Vacca L; IRCCS San Raffaele Roma, Rome, Italy., Guescini M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Zeppa SD; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy., Gatta L; Scientific Direction, IRCCS San Raffaele Roma, Rome, Italy., Stocchi F; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., Picconi B; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Rome, Italy., De Pandis MF; Department for the Promotion of Human Science and Quality of Life, San Raffaele University, Rome, Italy.; IRCCS San Raffaele Roma, Cassino, Italy. |
| Source: | Frontiers in aging neuroscience [Front Aging Neurosci] 2026 Mar 25; Vol. 18, pp. 1743490. Date of Electronic Publication: 2026 Mar 25 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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