FRMPD4, a causal gene for intellectual disability and epilepsy, is associated with X-linked non-syndromic hearing loss.

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Title: FRMPD4, a causal gene for intellectual disability and epilepsy, is associated with X-linked non-syndromic hearing loss.
Authors: Liedtke D; Institute of Clinical Genetics and Genomic Medicine, University Hospital Würzburg, Würzburg, Germany.; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Rak K; Department of Oto-Rhino-Laryngology, Head and Neck Surgery and the Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany., Schrode KM; Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hehlert P; Department of Cellular Neurobiology, University of Göttingen, Göttingen, Germany., Chamanrou N; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran., Bengl D; Institute of Clinical Genetics and Genomic Medicine, University Hospital Würzburg, Würzburg, Germany.; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Katana R; Department of Cellular Neurobiology, University of Göttingen, Göttingen, Germany., Heydaran S; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran., Doll J; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Han M; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Nanda I; Institute of Clinical Genetics and Genomic Medicine, University Hospital Würzburg, Würzburg, Germany.; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Senthilan PR; Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians-University of Würzburg, Am Hubland, Würzburg, Germany., Jürgens L; Department of Oto-Rhino-Laryngology, Head and Neck Surgery and the Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany., Bieniussa L; Department of Oto-Rhino-Laryngology, Head and Neck Surgery and the Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany., Voelker J; Department of Oto-Rhino-Laryngology, Head and Neck Surgery and the Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany., Neuner C; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Hofrichter MA; Institute of Clinical Genetics and Genomic Medicine, University Hospital Würzburg, Würzburg, Germany.; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Schröder J; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Schellens RTW; Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., de Vrieze E; Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., van Wijk E; Department of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Zechner U; Institute of Human Genetics, University Medical Center, Johannes Gutenberg University, Mainz, Germany., Herms S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, Switzerland.; Human Genomic Research Group, Department of Biomedicine, University of Basel, Switzerland., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, Switzerland.; Human Genomic Research Group, Department of Biomedicine, University of Basel, Switzerland.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany., Müller T; Department of Bioinformatics, Biocenter, Julius-Maximilians-University Würzburg, Würzburg, Germany., Dittrich M; Institute of Clinical Genetics and Genomic Medicine, University Hospital Würzburg, Würzburg, Germany.; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany.; Department of Bioinformatics, Biocenter, Julius-Maximilians-University Würzburg, Würzburg, Germany., Bartsch O; Human Genetics Unit, Medical Care Centre, Johannes Gutenberg University Mainz, Mainz, Germany., Krawitz PM; Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany., Klopocki E; Institute of Clinical Genetics and Genomic Medicine, University Hospital Würzburg, Würzburg, Germany.; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Shehata-Dieler W; Department of Oto-Rhino-Laryngology, Head and Neck Surgery and the Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany., Maroofian R; Department of Neuromuscular Disorders, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Wang T; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Worley PF; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Göpfert MC; Department of Cellular Neurobiology, University of Göttingen, Göttingen, Germany., Galehdari H; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran., Lauer AM; Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Haaf T; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany., Vona B; Institute of Human Genetics, Julius-Maximilians-University Würzburg, Würzburg, Germany.; Institute for Auditory Neuroscience and Inner Ear Lab, University Medical Center Göttingen, Göttingen, Germany.; Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Collaborative Research Center 1690 (CRC1690), University of Göttingen, Göttingen, Germany.; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 30. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.64898/2026.03.27.26349271