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Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.

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Title: Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.
Authors: Heydari D; Department of Human Genetics, McGill University, Montreal, Canada., Langlois S; Department of Human Genetics, McGill University, Montreal, Canada., Norouzi M; Research Institute of the McGill University Health Centre, Montreal, Canada., Myette RL; Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Canada., Samuel S; Division of Pediatric Nephrology, University of British Columbia, Vancouver, Canada., Zhou S; Department of Human Genetics, McGill University, Montreal, Canada., Takano T; Research Institute of the McGill University Health Centre, Montreal, Canada., Butler-Laporte G; Department of Human Genetics, McGill University, Montreal, Canada.; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Canada.; Division of Infectious Diseases, McGill University Health Centre, Montréal, Canada., Downie ML; Department of Human Genetics, McGill University, Montreal, Canada. mallory.downie@mcgill.ca.; Research Institute of the McGill University Health Centre, Montreal, Canada. mallory.downie@mcgill.ca.; Division of Pediatric Nephrology, Montréal Children's Hospital, Montréal, Canada. mallory.downie@mcgill.ca.
Source: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2026 Apr 10. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Heydari+D%22">Heydari D</searchLink>; Department of Human Genetics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Langlois+S%22">Langlois S</searchLink>; Department of Human Genetics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Norouzi+M%22">Norouzi M</searchLink>; Research Institute of the McGill University Health Centre, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Myette+RL%22">Myette RL</searchLink>; Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Canada.<br /><searchLink fieldCode="AU" term="%22Samuel+S%22">Samuel S</searchLink>; Division of Pediatric Nephrology, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Zhou+S%22">Zhou S</searchLink>; Department of Human Genetics, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Takano+T%22">Takano T</searchLink>; Research Institute of the McGill University Health Centre, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Butler-Laporte+G%22">Butler-Laporte G</searchLink>; Department of Human Genetics, McGill University, Montreal, Canada.; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Canada.; Division of Infectious Diseases, McGill University Health Centre, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Downie+ML%22">Downie ML</searchLink>; Department of Human Genetics, McGill University, Montreal, Canada. mallory.downie@mcgill.ca.; Research Institute of the McGill University Health Centre, Montreal, Canada. mallory.downie@mcgill.ca.; Division of Pediatric Nephrology, Montréal Children's Hospital, Montréal, Canada. mallory.downie@mcgill.ca.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8708728 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-198X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220931041X%22">0931041X </searchLink><i>NLM ISO Abbreviation: </i>Pediatr Nephrol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00467-026-07280-z
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      – Code: eng
        Text: English
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      – TitleFull: Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.
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            – D: 10
              M: 04
              Text: 2026 Apr 10
              Type: published
              Y: 2026
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