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Machine learning integrated clinical-proteomics data identifies a 6-protein panel signature for atherosclerotic severity and enhanced patient stratification.

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Title: Machine learning integrated clinical-proteomics data identifies a 6-protein panel signature for atherosclerotic severity and enhanced patient stratification.
Authors: Extremera-García MJ; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.; UGC Laboratory Medicine, University Hospital Puerta del Mar, Cádiz, Spain., Rojas-Torres M; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Priego-Torres B; Automation Engineering, Electronics and Computer Architecture and Networks Department, University of Cádiz, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain. blanca.priego@uca.es., Beltrán-Camacho L; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Eslava-Alcón S; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Rodríguez-Martín F; Institute of Biomedicine of Seville (IBIS), Virgen del Rocio University Hospital//CSIC/Dpt. Cell Biology, Faculty of Biology, University of Seville, Seville, Spain., Benítez-Camacho J; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Ballesteros-Ribelles A; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Del Val AM; National Center of Cardiovascular Research Carlos III (CNIC), Madrid, Spain.; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Olsen J; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Lozano-Loaiza E; Internal Medicine Unit, La Línea Hospital, La Línea de La Concepción, Cádiz, Spain., González-García MÁ; UGC Laboratory Medicine, University Hospital of Jerez de La Frontera, Cádiz, Spain., Sanchez-Morillo D; Automation Engineering, Electronics and Computer Architecture and Networks Department, University of Cádiz, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Fernández-Vega A; Neurovascular Research Group, Institute de Biomedicine of Seville, IBiS/Virgen, Macarena University Hospital/CSIC/University of Seville, Seville, Spain., Montaner J; Neurovascular Research Group, Institute de Biomedicine of Seville, IBiS/Virgen, Macarena University Hospital/CSIC/University of Seville, Seville, Spain., Doiz E; UGC Laboratory Medicine, University Hospital Puerta del Mar, Cádiz, Spain.; Angiology and Vascular Surgery Unit, University Hospital Puerta del Mar, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Rodriguez-Piñero M; UGC Laboratory Medicine, University Hospital Puerta del Mar, Cádiz, Spain.; Angiology and Vascular Surgery Unit, University Hospital Puerta del Mar, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain., Durán-Ruiz MC; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain. maricarmen.duran@gm.uca.es.
Source: Molecular biomedicine [Mol Biomed] 2026 Apr 10; Vol. 7 (1). Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Machine learning integrated clinical-proteomics data identifies a 6-protein panel signature for atherosclerotic severity and enhanced patient stratification.
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  Data: <searchLink fieldCode="AU" term="%22Extremera-García+MJ%22">Extremera-García MJ</searchLink>; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.; UGC Laboratory Medicine, University Hospital Puerta del Mar, Cádiz, Spain.<br /><searchLink fieldCode="AU" term="%22Rojas-Torres+M%22">Rojas-Torres M</searchLink>; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Priego-Torres+B%22">Priego-Torres B</searchLink>; Automation Engineering, Electronics and Computer Architecture and Networks Department, University of Cádiz, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain. blanca.priego@uca.es.<br /><searchLink fieldCode="AU" term="%22Beltrán-Camacho+L%22">Beltrán-Camacho L</searchLink>; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Eslava-Alcón+S%22">Eslava-Alcón S</searchLink>; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Martín+F%22">Rodríguez-Martín F</searchLink>; Institute of Biomedicine of Seville (IBIS), Virgen del Rocio University Hospital//CSIC/Dpt. Cell Biology, Faculty of Biology, University of Seville, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Benítez-Camacho+J%22">Benítez-Camacho J</searchLink>; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Ballesteros-Ribelles+A%22">Ballesteros-Ribelles A</searchLink>; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Val+AM%22">Del Val AM</searchLink>; National Center of Cardiovascular Research Carlos III (CNIC), Madrid, Spain.; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Olsen+J%22">Olsen J</searchLink>; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lozano-Loaiza+E%22">Lozano-Loaiza E</searchLink>; Internal Medicine Unit, La Línea Hospital, La Línea de La Concepción, Cádiz, Spain.<br /><searchLink fieldCode="AU" term="%22González-García+MÁ%22">González-García MÁ</searchLink>; UGC Laboratory Medicine, University Hospital of Jerez de La Frontera, Cádiz, Spain.<br /><searchLink fieldCode="AU" term="%22Sanchez-Morillo+D%22">Sanchez-Morillo D</searchLink>; Automation Engineering, Electronics and Computer Architecture and Networks Department, University of Cádiz, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Vega+A%22">Fernández-Vega A</searchLink>; Neurovascular Research Group, Institute de Biomedicine of Seville, IBiS/Virgen, Macarena University Hospital/CSIC/University of Seville, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Montaner+J%22">Montaner J</searchLink>; Neurovascular Research Group, Institute de Biomedicine of Seville, IBiS/Virgen, Macarena University Hospital/CSIC/University of Seville, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Doiz+E%22">Doiz E</searchLink>; UGC Laboratory Medicine, University Hospital Puerta del Mar, Cádiz, Spain.; Angiology and Vascular Surgery Unit, University Hospital Puerta del Mar, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Piñero+M%22">Rodriguez-Piñero M</searchLink>; UGC Laboratory Medicine, University Hospital Puerta del Mar, Cádiz, Spain.; Angiology and Vascular Surgery Unit, University Hospital Puerta del Mar, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain.<br /><searchLink fieldCode="AU" term="%22Durán-Ruiz+MC%22">Durán-Ruiz MC</searchLink>; Biomedicine, Biotechnology and Public Health Department, Cádiz University, Cádiz, Spain//Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain. maricarmen.duran@gm.uca.es.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
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