Naturally self-reactive B cells are poised to cross the selection barrier into autoimmune germinal centers.

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Title: Naturally self-reactive B cells are poised to cross the selection barrier into autoimmune germinal centers.
Authors: Yi-Dan Zhu D; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PhD Program in Virology, Harvard Medical School, Boston, MA, USA., Sangesland M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Okonkwo V; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Zhang Z; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PhD Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA., Rosado V; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Ronsard L; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., McCarthy C; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Alexander C; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Barnes RM; Bristol-Myers Squibb, Redwood City, CA, USA., Rohrer D; Bristol-Myers Squibb, Redwood City, CA, USA., Lonberg N; Bristol-Myers Squibb, Redwood City, CA, USA., Tagore D; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Ghebremichael M; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA; MGH Biostatistics, Boston, MA, USA., Castrillon C; Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Akey JM; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Carroll MC; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: michael.carroll@childrens.harvard.edu., Lingwood D; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA. Electronic address: dlingwood@mgh.harvard.edu.
Source: Cell reports [Cell Rep] 2026 Apr 08; Vol. 45 (4), pp. 117224. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Naturally self-reactive B cells are poised to cross the selection barrier into autoimmune germinal centers.
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  Data: <searchLink fieldCode="AU" term="%22Yi-Dan+Zhu+D%22">Yi-Dan Zhu D</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PhD Program in Virology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sangesland+M%22">Sangesland M</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Okonkwo+V%22">Okonkwo V</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PhD Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rosado+V%22">Rosado V</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ronsard+L%22">Ronsard L</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+C%22">McCarthy C</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+C%22">Alexander C</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Barnes+RM%22">Barnes RM</searchLink>; Bristol-Myers Squibb, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rohrer+D%22">Rohrer D</searchLink>; Bristol-Myers Squibb, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lonberg+N%22">Lonberg N</searchLink>; Bristol-Myers Squibb, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tagore+D%22">Tagore D</searchLink>; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Ghebremichael+M%22">Ghebremichael M</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA; MGH Biostatistics, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Castrillon+C%22">Castrillon C</searchLink>; Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Akey+JM%22">Akey JM</searchLink>; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Carroll+MC%22">Carroll MC</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: michael.carroll@childrens.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Lingwood+D%22">Lingwood D</searchLink>; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA. Electronic address: dlingwood@mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Apr 08; Vol. 45 (4), pp. 117224. <i>Date of Electronic Publication: </i>2026 Apr 08.
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              Text: 2026 Apr 08
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