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Combining CRP testing and patient information leaflets to safely reduce antibiotic use for acute respiratory tract infections in adults: Protocol for the 2CARE randomised controlled trial in Kyrgyz primary care.

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Title: Combining CRP testing and patient information leaflets to safely reduce antibiotic use for acute respiratory tract infections in adults: Protocol for the 2CARE randomised controlled trial in Kyrgyz primary care.
Authors: Akylbekov A; Department of Pulmonology, National Centre of Cardiology and Internal Medicine named after academician M. Mirrakhimov, Bishkek, Kyrgyzstan., Isaeva E; Department of Allergology, National Centre of Maternity and Childhood Care, Bishkek, Kyrgyzstan., Mademilov M; Department of Pulmonology, National Centre of Cardiology and Internal Medicine named after academician M. Mirrakhimov, Bishkek, Kyrgyzstan., Siersma V; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Risør T; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Arnold SH; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Kjærgaard J; Unit for children and adolescents with infections or organ-disease, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Sreenivasan N; International Centre for Antimicrobial Resistance Solutions (ICARS), Copenhagen, Denmark., Zaman AW; International Centre for Antimicrobial Resistance Solutions (ICARS), Copenhagen, Denmark., Sooronbaev T; Department of Pulmonology, National Centre of Cardiology and Internal Medicine named after academician M. Mirrakhimov, Bishkek, Kyrgyzstan., Aabenhus RM; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Source: PloS one [PLoS One] 2026 Apr 10; Vol. 21 (4), pp. e0345747. Date of Electronic Publication: 2026 Apr 10 (Print Publication: 2026).
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Combining CRP testing and patient information leaflets to safely reduce antibiotic use for acute respiratory tract infections in adults: Protocol for the 2CARE randomised controlled trial in Kyrgyz primary care.
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  Data: <searchLink fieldCode="AU" term="%22Akylbekov+A%22">Akylbekov A</searchLink>; Department of Pulmonology, National Centre of Cardiology and Internal Medicine named after academician M. Mirrakhimov, Bishkek, Kyrgyzstan.<br /><searchLink fieldCode="AU" term="%22Isaeva+E%22">Isaeva E</searchLink>; Department of Allergology, National Centre of Maternity and Childhood Care, Bishkek, Kyrgyzstan.<br /><searchLink fieldCode="AU" term="%22Mademilov+M%22">Mademilov M</searchLink>; Department of Pulmonology, National Centre of Cardiology and Internal Medicine named after academician M. Mirrakhimov, Bishkek, Kyrgyzstan.<br /><searchLink fieldCode="AU" term="%22Siersma+V%22">Siersma V</searchLink>; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Risør+T%22">Risør T</searchLink>; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Arnold+SH%22">Arnold SH</searchLink>; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kjærgaard+J%22">Kjærgaard J</searchLink>; Unit for children and adolescents with infections or organ-disease, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sreenivasan+N%22">Sreenivasan N</searchLink>; International Centre for Antimicrobial Resistance Solutions (ICARS), Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Zaman+AW%22">Zaman AW</searchLink>; International Centre for Antimicrobial Resistance Solutions (ICARS), Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sooronbaev+T%22">Sooronbaev T</searchLink>; Department of Pulmonology, National Centre of Cardiology and Internal Medicine named after academician M. Mirrakhimov, Bishkek, Kyrgyzstan.<br /><searchLink fieldCode="AU" term="%22Aabenhus+RM%22">Aabenhus RM</searchLink>; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Apr 10; Vol. 21 (4), pp. e0345747. <i>Date of Electronic Publication: </i>2026 Apr 10 (<i>Print Publication: </i>2026).
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