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Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery.

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Title: Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery.
Authors: Davey SD; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Forde-Thomas JE; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Hulme BJ; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Lees K; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Costain AH; Lydia Becker Institute of Immunology and Inflammation, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, England, Manchester M13 9NT, United Kingdom., Evans M; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Rinaldi G; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Frame L; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., Stojanovski L; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., Simeons FRC; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., Tavendale A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., MacLeod AK; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., Pichon R; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Lee YH; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.; Department of Computer Science, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Polak O; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Chalmers IW; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Dankwa B; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Odhiambo BK; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Guimaraes VH; Laboratory of Inflammation and Infectious Diseases, Department of Morphology and Pathology, Federal University of São Carlos, São Carlos CEP 13565-905, Brazil., Hegarty M; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Swain MT; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Aubrey W; Department of Computer Science, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom., Caldwell N; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., MacDonald AS; Lydia Becker Institute of Immunology and Inflammation, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, England, Manchester M13 9NT, United Kingdom., Gilbert IH; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., Baragaña B; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., Read KD; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom., Hoffmann KF; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 14; Vol. 123 (15), pp. e2600197123. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rinaldi+G%22">Rinaldi G</searchLink>; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Frame+L%22">Frame L</searchLink>; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stojanovski+L%22">Stojanovski L</searchLink>; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Simeons+FRC%22">Simeons FRC</searchLink>; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tavendale+A%22">Tavendale A</searchLink>; 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Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dankwa+B%22">Dankwa B</searchLink>; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Odhiambo+BK%22">Odhiambo BK</searchLink>; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Guimaraes+VH%22">Guimaraes VH</searchLink>; Laboratory of Inflammation and Infectious Diseases, Department of Morphology and Pathology, Federal University of São Carlos, São Carlos CEP 13565-905, Brazil.<br /><searchLink fieldCode="AU" term="%22Hegarty+M%22">Hegarty M</searchLink>; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Swain+MT%22">Swain MT</searchLink>; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Aubrey+W%22">Aubrey W</searchLink>; 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Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hoffmann+KF%22">Hoffmann KF</searchLink>; Department of Life Sciences, Aberystwyth University, Wales, Aberystwyth SY23 3DA, United Kingdom.
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