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A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina.

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Title: A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina.
Authors: Shen N; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Bright Center for Human Vision, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: ningshen@wustl.edu., Fitzpatrick MJ; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Graduate Program in Neuroscience, Division of Biological & Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA., Harding EG; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Rebba S; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Soto F; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Ruzycki PA; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: p.ruzycki@wustl.edu., Kerschensteiner D; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Bright Center for Human Vision, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: kerschensteinerd@wustl.edu.
Source: Neuron [Neuron] 2026 Apr 09. Date of Electronic Publication: 2026 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
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  Data: A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina.
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  Data: <searchLink fieldCode="AU" term="%22Shen+N%22">Shen N</searchLink>; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Bright Center for Human Vision, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: ningshen@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Fitzpatrick+MJ%22">Fitzpatrick MJ</searchLink>; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Graduate Program in Neuroscience, Division of Biological & Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Harding+EG%22">Harding EG</searchLink>; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Rebba+S%22">Rebba S</searchLink>; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Soto+F%22">Soto F</searchLink>; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Ruzycki+PA%22">Ruzycki PA</searchLink>; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: p.ruzycki@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Kerschensteiner+D%22">Kerschensteiner D</searchLink>; John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Bright Center for Human Vision, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: kerschensteinerd@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2026 Apr 09. <i>Date of Electronic Publication: </i>2026 Apr 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8809320 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4199 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208966273%22">08966273 </searchLink><i>NLM ISO Abbreviation: </i>Neuron <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.neuron.2026.03.022
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              Text: 2026 Apr 09
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