Efficacy and safety of short-cycle, dolutegravir-based antiretroviral therapy in adolescents living with HIV (BREATHER Plus): a multicentre, open-label, randomised, parallel, two-arm, non-inferiority trial.
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| Title: | Efficacy and safety of short-cycle, dolutegravir-based antiretroviral therapy in adolescents living with HIV (BREATHER Plus): a multicentre, open-label, randomised, parallel, two-arm, non-inferiority trial. |
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| Authors: | Kekitiinwa AR; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Jennings A; Medical Research Council Clinical Trials Unit at UCL, London, UK., Bwakura-Dangarembizi M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Kityo C; Joint Clinical Research Centre, Kampala, Uganda., Siika A; Moi University Clinical Research Centre, Eldoret, Kenya., Archary M; Department of Paediatrics and Children Health, Victoria Mxenge Hospital, Enhancing Care Foundation, Durban, South Africa; Africa Health Research Institute, Nelson R Mandela School of Medicine, Durban, South Africa., Green A; Medical Research Council Clinical Trials Unit at UCL, London, UK., Jafta L; Fondazione Penta ETS, Padova, Italy., Akabwai GP; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Mugerwa H; Joint Clinical Research Centre, Kampala, Uganda., Kiilu C; Moi University Clinical Research Centre, Eldoret, Kenya., Mngqibisa R; Department of Paediatrics and Children Health, Victoria Mxenge Hospital, Enhancing Care Foundation, Durban, South Africa., Seeley J; Medical Research Council-Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda; Africa Health Research Institute, Nelson R Mandela School of Medicine, Durban, South Africa; Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK., Nazzinda R; Joint Clinical Research Centre, Kampala, Uganda., Apoto N; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Walker S; Centre for Health Economics, University of York, York, UK., Burger D; Department of Pharmacy, Pharmacology and Toxicology, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands., Giaquinto C; Fondazione Penta ETS, Padova, Italy., Okello RB; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Musoro G; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Wambui C; Moi University Clinical Research Centre, Eldoret, Kenya., Arumugam T; Department of Paediatrics and Children Health, Victoria Mxenge Hospital, Enhancing Care Foundation, Durban, South Africa., Conway M; Fondazione Penta ETS, Padova, Italy., Van Looy N; Medical Research Council Clinical Trials Unit at UCL, London, UK., South A; Medical Research Council Clinical Trials Unit at UCL, London, UK., Bamford A; Medical Research Council Clinical Trials Unit at UCL, London, UK., Thomason MJ; Medical Research Council Clinical Trials Unit at UCL, London, UK., Ford D; Medical Research Council Clinical Trials Unit at UCL, London, UK. Electronic address: deborah.ford@ucl.ac.uk., Pett SL; Medical Research Council Clinical Trials Unit at UCL, London, UK. |
| Corporate Authors: | BREATHER Plus trial team |
| Source: | The lancet. HIV [Lancet HIV] 2026 Jun; Vol. 13 (6), pp. e367-e379. Date of Electronic Publication: 2026 Apr 07. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Equivalence Trial |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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