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A systematic review and meta-analysis of the relationship between midlife physical activity and later-life cognition: Is sex an overlooked factor?

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Title: A systematic review and meta-analysis of the relationship between midlife physical activity and later-life cognition: Is sex an overlooked factor?
Authors: Burma JS; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada., Nel JH; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada., Cheung H; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada., Hofforth D; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada., Zala D; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada., Hayden KA; Libraries & Cultural Resources, University of Calgary, Calgary, Alberta, Canada., Ronksley PE; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada., Carty CL; IREACH, Washington State University, Seattle, WA, United States of America., Chang M; Association of Healthy Aging, Reykjavik, Iceland., Gross AL; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America., James SN; MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, United Kingdom., Kesse-Guyot E; Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Center of Research in Epidemiology and Statistics (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France., Rodriguez-Espinosa N; Department of Neurology, University Hospital Nuestra Señora de Candelaria, Tenerife, Spain; Department of Internal Medicine, Dermatology and Psychiatry, Faculty of Health Sciences, University of La Laguna, Tenerife, Spain., Yaffe K; Departments of Psychiatry, Neurology and Epidemiology and the Weil Institute for Neuroscience, University of California, San Francisco, CA, United States of America., Barha CK; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. Electronic address: Cindy.Barha@ucalgary.ca.
Source: Frontiers in neuroendocrinology [Front Neuroendocrinol] 2026 Apr; Vol. 81, pp. 101250. Date of Electronic Publication: 2026 Apr 08.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 7513292 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6808 (Electronic) Linking ISSN: 00913022 NLM ISO Abbreviation: Front Neuroendocrinol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A systematic review and meta-analysis of the relationship between midlife physical activity and later-life cognition: Is sex an overlooked factor?
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  Data: <searchLink fieldCode="AU" term="%22Burma+JS%22">Burma JS</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Nel+JH%22">Nel JH</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Cheung+H%22">Cheung H</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Hofforth+D%22">Hofforth D</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Zala+D%22">Zala D</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Hayden+KA%22">Hayden KA</searchLink>; Libraries & Cultural Resources, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Ronksley+PE%22">Ronksley PE</searchLink>; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Carty+CL%22">Carty CL</searchLink>; IREACH, Washington State University, Seattle, WA, United States of America.<br /><searchLink fieldCode="AU" term="%22Chang+M%22">Chang M</searchLink>; Association of Healthy Aging, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gross+AL%22">Gross AL</searchLink>; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.<br /><searchLink fieldCode="AU" term="%22James+SN%22">James SN</searchLink>; MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kesse-Guyot+E%22">Kesse-Guyot E</searchLink>; Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Center of Research in Epidemiology and Statistics (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Espinosa+N%22">Rodriguez-Espinosa N</searchLink>; Department of Neurology, University Hospital Nuestra Señora de Candelaria, Tenerife, Spain; Department of Internal Medicine, Dermatology and Psychiatry, Faculty of Health Sciences, University of La Laguna, Tenerife, Spain.<br /><searchLink fieldCode="AU" term="%22Yaffe+K%22">Yaffe K</searchLink>; Departments of Psychiatry, Neurology and Epidemiology and the Weil Institute for Neuroscience, University of California, San Francisco, CA, United States of America.<br /><searchLink fieldCode="AU" term="%22Barha+CK%22">Barha CK</searchLink>; Barha Brain Health Laboratory, Faculty of Kinesiology, University of Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. Electronic address: Cindy.Barha@ucalgary.ca.
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