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Early metabolic alterations in pediatric obesity: Depot-specific insights from untargeted adipose tissue metabolomics.

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Title: Early metabolic alterations in pediatric obesity: Depot-specific insights from untargeted adipose tissue metabolomics.
Authors: López-Gonzálvez Á; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano)., Muñoz-San Martín C; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano)., Soria-Gondek A; Pediatric Surgery Department, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Spain (Soria-Gondek)., Requena B; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano)., Fernández-García P; Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), E-28922 Madrid, Spain (Fernández-García, Corrales, and Sánchez-Infantes)., González L; Fundació Institut Germans Trias i Pujol, Barcelona 08916, Spain (González and Reyes-Farias)., Reyes-Farias M; Fundació Institut Germans Trias i Pujol, Barcelona 08916, Spain (González and Reyes-Farias); Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain (Reyes-Farias and Herrero)., Murillo M; Pediatric Endocrinology Unit, Pediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Spain (Murillo and Valls)., Valls A; Pediatric Endocrinology Unit, Pediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Spain (Murillo and Valls)., Corrales P; Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), E-28922 Madrid, Spain (Fernández-García, Corrales, and Sánchez-Infantes)., Villarroya F; Biochemistry and Molecular biomedicine Department, Instituto de Biomedicina de la Universidad de Barcelona, Barcelona 08028, Spain (Villarroya and Cereijo); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes)., Cereijo R; Biochemistry and Molecular biomedicine Department, Instituto de Biomedicina de la Universidad de Barcelona, Barcelona 08028, Spain (Villarroya and Cereijo); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes)., Herrero L; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain (Reyes-Farias and Herrero); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes)., Barbas C; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano)., Sánchez-Infantes D; Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), E-28922 Madrid, Spain (Fernández-García, Corrales, and Sánchez-Infantes); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes). Electronic address: david.sanchezi@urjc.es., Gonzalez-Riano C; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano). Electronic address: carolina.gonzalezriano@ceu.es.
Source: Journal of clinical lipidology [J Clin Lipidol] 2026 Jun; Vol. 20 (6), pp. 1196-1211. Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101300157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-2874 (Print) Linking ISSN: 18764789 NLM ISO Abbreviation: J Clin Lipidol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early metabolic alterations in pediatric obesity: Depot-specific insights from untargeted adipose tissue metabolomics.
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  Data: <searchLink fieldCode="AU" term="%22López-Gonzálvez+Á%22">López-Gonzálvez Á</searchLink>; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano).<br /><searchLink fieldCode="AU" term="%22Muñoz-San+Martín+C%22">Muñoz-San Martín C</searchLink>; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano).<br /><searchLink fieldCode="AU" term="%22Soria-Gondek+A%22">Soria-Gondek A</searchLink>; Pediatric Surgery Department, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Spain (Soria-Gondek).<br /><searchLink fieldCode="AU" term="%22Requena+B%22">Requena B</searchLink>; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano).<br /><searchLink fieldCode="AU" term="%22Fernández-García+P%22">Fernández-García P</searchLink>; Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), E-28922 Madrid, Spain (Fernández-García, Corrales, and Sánchez-Infantes).<br /><searchLink fieldCode="AU" term="%22González+L%22">González L</searchLink>; Fundació Institut Germans Trias i Pujol, Barcelona 08916, Spain (González and Reyes-Farias).<br /><searchLink fieldCode="AU" term="%22Reyes-Farias+M%22">Reyes-Farias M</searchLink>; Fundació Institut Germans Trias i Pujol, Barcelona 08916, Spain (González and Reyes-Farias); Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain (Reyes-Farias and Herrero).<br /><searchLink fieldCode="AU" term="%22Murillo+M%22">Murillo M</searchLink>; Pediatric Endocrinology Unit, Pediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Spain (Murillo and Valls).<br /><searchLink fieldCode="AU" term="%22Valls+A%22">Valls A</searchLink>; Pediatric Endocrinology Unit, Pediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Spain (Murillo and Valls).<br /><searchLink fieldCode="AU" term="%22Corrales+P%22">Corrales P</searchLink>; Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), E-28922 Madrid, Spain (Fernández-García, Corrales, and Sánchez-Infantes).<br /><searchLink fieldCode="AU" term="%22Villarroya+F%22">Villarroya F</searchLink>; Biochemistry and Molecular biomedicine Department, Instituto de Biomedicina de la Universidad de Barcelona, Barcelona 08028, Spain (Villarroya and Cereijo); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes).<br /><searchLink fieldCode="AU" term="%22Cereijo+R%22">Cereijo R</searchLink>; Biochemistry and Molecular biomedicine Department, Instituto de Biomedicina de la Universidad de Barcelona, Barcelona 08028, Spain (Villarroya and Cereijo); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes).<br /><searchLink fieldCode="AU" term="%22Herrero+L%22">Herrero L</searchLink>; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain (Reyes-Farias and Herrero); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes).<br /><searchLink fieldCode="AU" term="%22Barbas+C%22">Barbas C</searchLink>; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano).<br /><searchLink fieldCode="AU" term="%22Sánchez-Infantes+D%22">Sánchez-Infantes D</searchLink>; Department of Health Sciences, Campus Alcorcón, University Rey Juan Carlos (URJC), E-28922 Madrid, Spain (Fernández-García, Corrales, and Sánchez-Infantes); Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid 28029, Spain (Villarroya, Cereijo, Herrero, and Sánchez-Infantes). Electronic address: david.sanchezi@urjc.es.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Riano+C%22">Gonzalez-Riano C</searchLink>; Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización MonteprÍncipe, 28660 Boadilla del Monte, Spain (López-Gonzálvez, Martín, Requena, Barbas, and Gonzalez-Riano). Electronic address: carolina.gonzalezriano@ceu.es.
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  Data: <searchLink fieldCode="JN" term="%22101300157%22">Journal of clinical lipidology</searchLink> [J Clin Lipidol] 2026 Jun; Vol. 20 (6), pp. 1196-1211. <i>Date of Electronic Publication: </i>2026 Mar 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101300157 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1933-2874 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218764789%22">18764789 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Lipidol <i>Subsets: </i>MEDLINE
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