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Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy.

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Title: Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy.
Authors: Chung JY; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea., Hong J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Yee SM; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea., Lim HW; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Lee D; Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Yoon S; Corporate Research & Development Center, UCI Therapeutics, Seoul, 04784, Republic of Korea., Lee SH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.; Ottawa Institute of Systems Biology, Faculty of Medicine and Centre for Infection, Immunity, and Inflammation, Faculty of Medicine, University of Ottawa, Ontario, K1N 6N5, Canada., Jung Y; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Shin SH; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea., Kim SC; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 05505, Seoul, Republic of Korea., Lee CH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; BK21 FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; Wide River Institute of Immunology, Seoul National University, Hongcheon, 25159, Republic of Korea. chlee-antibody@snu.ac.kr., Jang M; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea. mihue@kist.re.kr.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea. mihue@kist.re.kr.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul, 02792, Republic of Korea. mihue@kist.re.kr.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Apr 10; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chung+JY%22">Chung JY</searchLink>; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hong+J%22">Hong J</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yee+SM%22">Yee SM</searchLink>; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+HW%22">Lim HW</searchLink>; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+S%22">Yoon S</searchLink>; Corporate Research & Development Center, UCI Therapeutics, Seoul, 04784, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.; Ottawa Institute of Systems Biology, Faculty of Medicine and Centre for Infection, Immunity, and Inflammation, Faculty of Medicine, University of Ottawa, Ontario, K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Jung+Y%22">Jung Y</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shin+SH%22">Shin SH</searchLink>; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SC%22">Kim SC</searchLink>; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, 05505, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+CH%22">Lee CH</searchLink>; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; Department of Pharmacology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; BK21 FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea. chlee-antibody@snu.ac.kr.; Wide River Institute of Immunology, Seoul National University, Hongcheon, 25159, Republic of Korea. chlee-antibody@snu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Jang+M%22">Jang M</searchLink>; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea. mihue@kist.re.kr.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea. mihue@kist.re.kr.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul, 02792, Republic of Korea. mihue@kist.re.kr.
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              Text: 2026 Apr 10
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