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Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach.

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Title: Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach.
Authors: Sundheimer JK; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany. j.sundheimer@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany. j.sundheimer@kitz-heidelberg.de.; Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120, Heidelberg, Germany. j.sundheimer@kitz-heidelberg.de., Benzel J; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Federico A; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Volz S; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Knoll M; Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Statz B; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Zheng T; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Kmiecik SW; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Burhenne J; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Bajraktari-Sylejmani G; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Scheuermann S; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of General Pediatrics, Hematology and Oncology, University Children's Hospital Tuebingen, Tübingen, Germany.; University of Tuebingen, iFIT Cluster of ExCellence (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Tübingen, Germany.; German Cancer Research Consortium (DKTK), Partner Site Tuebingen, German Cancer Research Center (DKFZ), Heidelberg, Germany., King A; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Müller T; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hübner JM; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany., Kalxdorf M; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Peterziel H; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany., Oehme I; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany., Krijgsveld J; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Seitz CM; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kool M; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology and University Medical Center Utrecht (UMCU), Utrecht, The Netherlands., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120, Heidelberg, Germany., Pajtler KW; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120, Heidelberg, Germany., Maaß KK; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Source: Scientific reports [Sci Rep] 2026 Apr 10; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Sundheimer+JK%22">Sundheimer JK</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany. j.sundheimer@kitz-heidelberg.de.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany. j.sundheimer@kitz-heidelberg.de.; Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120, Heidelberg, Germany. j.sundheimer@kitz-heidelberg.de.<br /><searchLink fieldCode="AU" term="%22Benzel+J%22">Benzel J</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Federico+A%22">Federico A</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; 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Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kmiecik+SW%22">Kmiecik SW</searchLink>; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Burhenne+J%22">Burhenne J</searchLink>; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bajraktari-Sylejmani+G%22">Bajraktari-Sylejmani G</searchLink>; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Scheuermann+S%22">Scheuermann S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of General Pediatrics, Hematology and Oncology, University Children's Hospital Tuebingen, Tübingen, Germany.; University of Tuebingen, iFIT Cluster of ExCellence (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Tübingen, Germany.; German Cancer Research Consortium (DKTK), Partner Site Tuebingen, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22King+A%22">King A</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+T%22">Müller T</searchLink>; 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Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Krijgsveld+J%22">Krijgsveld J</searchLink>; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Seitz+CM%22">Seitz CM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kool+M%22">Kool M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology and University Medical Center Utrecht (UMCU), Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pajtler+KW%22">Pajtler KW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Maaß+KK%22">Maaß KK</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.; Heidelberg Faculty of Medicine, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
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