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Vaccine elicitation of HIV broadly neutralizing antibodies from genome-edited B cells in non-human primates and derived lymphoid organoids.

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Title: Vaccine elicitation of HIV broadly neutralizing antibodies from genome-edited B cells in non-human primates and derived lymphoid organoids.
Authors: Tenuta M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Bravo M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Olson A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Saney CL; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA., Weinfurter J; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA., Ben-Akiva E; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Bhange D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Cottrell CA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA., Vosler L; Immunology Services, Wisconsin National Primate Research Center, Madison, WI, USA.; AIDS Vaccine Research Laboratory, University of Wisconsin, Madison, WI, USA., Weisgrau K; Immunology Services, Wisconsin National Primate Research Center, Madison, WI, USA.; AIDS Vaccine Research Laboratory, University of Wisconsin, Madison, WI, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA., Irvine DJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA.; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Schief WR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Moderna, Cambridge, MA, USA., Rakasz E; Immunology Services, Wisconsin National Primate Research Center, Madison, WI, USA.; AIDS Vaccine Research Laboratory, University of Wisconsin, Madison, WI, USA., Joyner CJ; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA. cjjoyne@uga.edu.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA. cjjoyne@uga.edu.; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA. cjjoyne@uga.edu., Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. jvoss@scripps.edu.
Source: Gene therapy [Gene Ther] 2026 Apr 10. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
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  Data: Vaccine elicitation of HIV broadly neutralizing antibodies from genome-edited B cells in non-human primates and derived lymphoid organoids.
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  Data: <searchLink fieldCode="AU" term="%22Tenuta+M%22">Tenuta M</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bravo+M%22">Bravo M</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Olson+A%22">Olson A</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saney+CL%22">Saney CL</searchLink>; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Weinfurter+J%22">Weinfurter J</searchLink>; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Ben-Akiva+E%22">Ben-Akiva E</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bhange+D%22">Bhange D</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cottrell+CA%22">Cottrell CA</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vosler+L%22">Vosler L</searchLink>; Immunology Services, Wisconsin National Primate Research Center, Madison, WI, USA.; AIDS Vaccine Research Laboratory, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Weisgrau+K%22">Weisgrau K</searchLink>; Immunology Services, Wisconsin National Primate Research Center, Madison, WI, USA.; AIDS Vaccine Research Laboratory, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Irvine+DJ%22">Irvine DJ</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA.; The Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Schief+WR%22">Schief WR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Moderna, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rakasz+E%22">Rakasz E</searchLink>; Immunology Services, Wisconsin National Primate Research Center, Madison, WI, USA.; AIDS Vaccine Research Laboratory, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Joyner+CJ%22">Joyner CJ</searchLink>; Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA. cjjoyne@uga.edu.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA. cjjoyne@uga.edu.; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA. cjjoyne@uga.edu.<br /><searchLink fieldCode="AU" term="%22Voss+JE%22">Voss JE</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. jvoss@scripps.edu.
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