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Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice.

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Title: Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice.
Authors: Luo X; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China., Pei YR; Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China., Yu W; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China., Dai YL; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China., Xiong ZW; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China., Jia YB; Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China., Zhang L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China. zhangli@jnu.edu.cn.; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, 266114, China. zhangli@jnu.edu.cn.; The Third Affiliated Hospital of Henan Medical University, Xinxiang, 453000, China. zhangli@jnu.edu.cn., Zhang BR; Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China. borui_zhang@foxmail.com.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Aug; Vol. 47 (8), pp. 2083-2093. Date of Electronic Publication: 2026 Apr 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice.
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  Data: <searchLink fieldCode="AU" term="%22Luo+X%22">Luo X</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Pei+YR%22">Pei YR</searchLink>; Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Yu+W%22">Yu W</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Dai+YL%22">Dai YL</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Xiong+ZW%22">Xiong ZW</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Jia+YB%22">Jia YB</searchLink>; Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China. zhangli@jnu.edu.cn.; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, 266114, China. zhangli@jnu.edu.cn.; The Third Affiliated Hospital of Henan Medical University, Xinxiang, 453000, China. zhangli@jnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+BR%22">Zhang BR</searchLink>; Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China. borui_zhang@foxmail.com.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Aug; Vol. 47 (8), pp. 2083-2093. <i>Date of Electronic Publication: </i>2026 Apr 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1038/s41401-026-01785-x
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        Text: English
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              M: 08
              Text: 2026 Aug
              Type: published
              Y: 2026
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