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Interpretable deep generative ensemble learning for single-cell omics with Hydra.

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Title: Interpretable deep generative ensemble learning for single-cell omics with Hydra.
Authors: Wagle MM; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia.; Computational Systems Biology Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.; Sydney Precision Data Science Center, The University of Sydney, Camperdown, NSW, Australia.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu C; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia.; Computational Systems Biology Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Liu Z; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational Biology Group, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang Y; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational Biology Group, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kellis M; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational Biology Group, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Patrick E; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia. ellis.patrick@sydney.edu.au.; Sydney Precision Data Science Center, The University of Sydney, Camperdown, NSW, Australia. ellis.patrick@sydney.edu.au.; Charles Perkins Center, The University of Sydney, Camperdown, NSW, Australia. ellis.patrick@sydney.edu.au.; Center for Cancer Research, Westmead Institute for Medical Research, Westmead, NSW, Australia. ellis.patrick@sydney.edu.au., Yang P; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia. pengyi.yang@sydney.edu.au.; Computational Systems Biology Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia. pengyi.yang@sydney.edu.au.; Sydney Precision Data Science Center, The University of Sydney, Camperdown, NSW, Australia. pengyi.yang@sydney.edu.au.; Charles Perkins Center, The University of Sydney, Camperdown, NSW, Australia. pengyi.yang@sydney.edu.au.
Source: Molecular systems biology [Mol Syst Biol] 2026 Jul; Vol. 22 (7), pp. 1161-1179. Date of Electronic Publication: 2026 Apr 11.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interpretable deep generative ensemble learning for single-cell omics with Hydra.
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  Data: <searchLink fieldCode="AU" term="%22Wagle+MM%22">Wagle MM</searchLink>; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia.; Computational Systems Biology Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.; Sydney Precision Data Science Center, The University of Sydney, Camperdown, NSW, Australia.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia.; Computational Systems Biology Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational Biology Group, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational Biology Group, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kellis+M%22">Kellis M</searchLink>; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational Biology Group, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Patrick+E%22">Patrick E</searchLink>; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia. ellis.patrick@sydney.edu.au.; Sydney Precision Data Science Center, The University of Sydney, Camperdown, NSW, Australia. ellis.patrick@sydney.edu.au.; Charles Perkins Center, The University of Sydney, Camperdown, NSW, Australia. ellis.patrick@sydney.edu.au.; Center for Cancer Research, Westmead Institute for Medical Research, Westmead, NSW, Australia. ellis.patrick@sydney.edu.au.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia. pengyi.yang@sydney.edu.au.; Computational Systems Biology Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia. pengyi.yang@sydney.edu.au.; Sydney Precision Data Science Center, The University of Sydney, Camperdown, NSW, Australia. pengyi.yang@sydney.edu.au.; Charles Perkins Center, The University of Sydney, Camperdown, NSW, Australia. pengyi.yang@sydney.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101235389%22">Molecular systems biology</searchLink> [Mol Syst Biol] 2026 Jul; Vol. 22 (7), pp. 1161-1179. <i>Date of Electronic Publication: </i>2026 Apr 11.
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              Text: 2026 Jul
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