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Wendan tablet and its active component isocurcumenol protect against myocardial ischemia via targeting ALOX15 and inhibiting lipid peroxidation.

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Title: Wendan tablet and its active component isocurcumenol protect against myocardial ischemia via targeting ALOX15 and inhibiting lipid peroxidation.
Authors: Ma XH; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China., Liu JH; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China., Chen CL; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China., Wu CS; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cell Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, Fujian, China; Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, Xiamen University, Xiamen, 361005, China., Lu D; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cell Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, Fujian, China., He LL; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China., Wu YP; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China., Chen Y; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China. Electronic address: 646926565@qq.com., He RR; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China. Electronic address: rongronghe@jnu.edu.cn., Yuan T; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; General Practice Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510405, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou 510006, China. Electronic address: gzyyth@gzucm.edu.cn.
Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jun; Vol. 155, pp. 158109. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Wendan tablet and its active component isocurcumenol protect against myocardial ischemia via targeting ALOX15 and inhibiting lipid peroxidation.
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  Data: <searchLink fieldCode="AU" term="%22Ma+XH%22">Ma XH</searchLink>; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.<br /><searchLink fieldCode="AU" term="%22Liu+JH%22">Liu JH</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.<br /><searchLink fieldCode="AU" term="%22Chen+CL%22">Chen CL</searchLink>; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China.<br /><searchLink fieldCode="AU" term="%22Wu+CS%22">Wu CS</searchLink>; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cell Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, Fujian, China; Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, Xiamen University, Xiamen, 361005, China.<br /><searchLink fieldCode="AU" term="%22Lu+D%22">Lu D</searchLink>; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cell Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, Fujian, China.<br /><searchLink fieldCode="AU" term="%22He+LL%22">He LL</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.<br /><searchLink fieldCode="AU" term="%22Wu+YP%22">Wu YP</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China. Electronic address: 646926565@qq.com.<br /><searchLink fieldCode="AU" term="%22He+RR%22">He RR</searchLink>; Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment/Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs/Institute of Traditional Chinese Medicine and Natural Products/Guangdong Engineering Research Center of Traditional Chinese Medicine & Disease Susceptibility/Guangdong Engineering Research Center of Traditional Chinese Medicine & Health Products/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China. Electronic address: rongronghe@jnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yuan+T%22">Yuan T</searchLink>; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; General Practice Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510405, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou 510006, China. Electronic address: gzyyth@gzucm.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229438794%22">Phytomedicine : international journal of phytotherapy and phytopharmacology</searchLink> [Phytomedicine] 2026 Jun; Vol. 155, pp. 158109. <i>Date of Electronic Publication: </i>2026 Mar 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Urban+%26+Fischer+Verlag%22">Urban & Fischer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9438794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-095X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209447113%22">09447113 </searchLink><i>NLM ISO Abbreviation: </i>Phytomedicine <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41966026
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.phymed.2026.158109
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      – Code: eng
        Text: English
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        StartPage: 158109
    Titles:
      – TitleFull: Wendan tablet and its active component isocurcumenol protect against myocardial ischemia via targeting ALOX15 and inhibiting lipid peroxidation.
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            NameFull: Ma XH
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            NameFull: Liu JH
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            NameFull: Chen CL
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 155
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            – TitleFull: Phytomedicine : international journal of phytotherapy and phytopharmacology
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