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Toxicological Evaluation of Vanillin Flavor in E-Liquid Aerosols on Endothelial Cell Function: Findings from the Replica Project.

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Title: Toxicological Evaluation of Vanillin Flavor in E-Liquid Aerosols on Endothelial Cell Function: Findings from the Replica Project.
Authors: Emma R; Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Department of Medicine and Surgery, 'Kore' University of Enna, 94100, Contrada Santa Panasia, Enna, Italy., Sun A; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA.; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA., Partsinevelos K; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy., Rust S; ECLAT Srl, spin off of the University of Catania, Via. S Sofia 89, Catania, 95123, Italy., Volarevic V; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.; Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia., Lesmana R; Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.; Division of Biological Activity, Central Laboratory, Universitas Padjadjaran, Bandung, Indonesia.; Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia., Giordano A; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA.; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Goenawan H; Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.; Division of Biological Activity, Central Laboratory, Universitas Padjadjaran, Bandung, Indonesia.; Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia., Barliana MI; Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.; Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Ir. Soekarno Km 21, Jatinangor, 45363, Indonesia., Arsenijevic A; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia., Kastratovic N; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia., Markovic V; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia., Spasic B; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia., Distefano A; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy., Orlando L; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy., Carota G; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy., Polosa R; Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy., Caruso M; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy. mascaru@unict.it.; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA. mascaru@unict.it.; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy. mascaru@unict.it., Li Volti G; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy.
Source: Cardiovascular toxicology [Cardiovasc Toxicol] 2026 Apr 13; Vol. 26 (4). Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 101135818 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0259 (Electronic) Linking ISSN: 15307905 NLM ISO Abbreviation: Cardiovasc Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Toxicological Evaluation of Vanillin Flavor in E-Liquid Aerosols on Endothelial Cell Function: Findings from the Replica Project.
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  Data: <searchLink fieldCode="AU" term="%22Emma+R%22">Emma R</searchLink>; Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Department of Medicine and Surgery, 'Kore' University of Enna, 94100, Contrada Santa Panasia, Enna, Italy.<br /><searchLink fieldCode="AU" term="%22Sun+A%22">Sun A</searchLink>; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA.; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA.<br /><searchLink fieldCode="AU" term="%22Partsinevelos+K%22">Partsinevelos K</searchLink>; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy.<br /><searchLink fieldCode="AU" term="%22Rust+S%22">Rust S</searchLink>; ECLAT Srl, spin off of the University of Catania, Via. S Sofia 89, Catania, 95123, Italy.<br /><searchLink fieldCode="AU" term="%22Volarevic+V%22">Volarevic V</searchLink>; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.; Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.<br /><searchLink fieldCode="AU" term="%22Lesmana+R%22">Lesmana R</searchLink>; Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.; Division of Biological Activity, Central Laboratory, Universitas Padjadjaran, Bandung, Indonesia.; Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.<br /><searchLink fieldCode="AU" term="%22Giordano+A%22">Giordano A</searchLink>; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA.; Department of Medical Biotechnologies, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Goenawan+H%22">Goenawan H</searchLink>; Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.; Division of Biological Activity, Central Laboratory, Universitas Padjadjaran, Bandung, Indonesia.; Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.<br /><searchLink fieldCode="AU" term="%22Barliana+MI%22">Barliana MI</searchLink>; Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.; Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. 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Soekarno Km 21, Jatinangor, 45363, Indonesia.<br /><searchLink fieldCode="AU" term="%22Arsenijevic+A%22">Arsenijevic A</searchLink>; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.<br /><searchLink fieldCode="AU" term="%22Kastratovic+N%22">Kastratovic N</searchLink>; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.<br /><searchLink fieldCode="AU" term="%22Markovic+V%22">Markovic V</searchLink>; Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica 69, Kragujevac, 34000, Serbia.; Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.<br /><searchLink fieldCode="AU" term="%22Spasic+B%22">Spasic B</searchLink>; Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia.<br /><searchLink fieldCode="AU" term="%22Distefano+A%22">Distefano A</searchLink>; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy.<br /><searchLink fieldCode="AU" term="%22Orlando+L%22">Orlando L</searchLink>; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy.<br /><searchLink fieldCode="AU" term="%22Carota+G%22">Carota G</searchLink>; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy.<br /><searchLink fieldCode="AU" term="%22Polosa+R%22">Polosa R</searchLink>; Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Caruso+M%22">Caruso M</searchLink>; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy. mascaru@unict.it.; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USA. mascaru@unict.it.; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy. mascaru@unict.it.<br /><searchLink fieldCode="AU" term="%22Li+Volti+G%22">Li Volti G</searchLink>; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Via S. Sofia, 97, 95123, Catania, Italy.; Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 97, Catania, 95123, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101135818%22">Cardiovascular toxicology</searchLink> [Cardiovasc Toxicol] 2026 Apr 13; Vol. 26 (4). <i>Date of Electronic Publication: </i>2026 Apr 13.
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