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Early lumbar drainage plus intrathecal urokinase in severe aneurysmal subarachnoid hemorrhage: the LD-ITUK randomized controlled trial protocol.

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Title: Early lumbar drainage plus intrathecal urokinase in severe aneurysmal subarachnoid hemorrhage: the LD-ITUK randomized controlled trial protocol.
Authors: Wu M; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China., Yan T; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China., Hu P; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China., Wang C; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China., Ye M; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China., Yu Z; Institute of Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200230, China., Wang Y; Division of Public Health Science, Washington University School of Medicine in St. Louis, 660 S. Euclid Ave. St. Louis, St. Louis, MO, 63110, USA., Mao G; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China., Xiao B; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China., Gong Y; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China., Li J; Clinical Trial Research Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. ndefy03048@ncu.edu.cn., Zhao R; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. z_ray1979@126.com.; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. z_ray1979@126.com., Yang P; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. p.yang@vip.163.com.; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. p.yang@vip.163.com., Liu J; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. liu118@vip.163.com.; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. liu118@vip.163.com., Zhu X; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China. zxg2008vip@163.com.; Jiangxi Province Key Laboratory of Neurological Diseases, Nanchang, PR China. zxg2008vip@163.com.; Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China. zxg2008vip@163.com.; Jiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi Province, 330000, PR China. zxg2008vip@163.com.; Jiangxi Key Laboratory of Neurological Tumors and Cerebrovascular Diseases; Jiangxi Health Commission Key Laboratory of Neurological Medicine, Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330006, China. zxg2008vip@163.com.
Corporate Authors: LD-ITUK Investigators
Source: Trials [Trials] 2026 Apr 13; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Early lumbar drainage plus intrathecal urokinase in severe aneurysmal subarachnoid hemorrhage: the LD-ITUK randomized controlled trial protocol.
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  Data: <searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China.<br /><searchLink fieldCode="AU" term="%22Yan+T%22">Yan T</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China.<br /><searchLink fieldCode="AU" term="%22Hu+P%22">Hu P</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.<br /><searchLink fieldCode="AU" term="%22Ye+M%22">Ye M</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Institute of Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200230, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Division of Public Health Science, Washington University School of Medicine in St. Louis, 660 S. Euclid Ave. St. Louis, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Mao+G%22">Mao G</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China.<br /><searchLink fieldCode="AU" term="%22Xiao+B%22">Xiao B</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China.<br /><searchLink fieldCode="AU" term="%22Gong+Y%22">Gong Y</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Clinical Trial Research Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. ndefy03048@ncu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+R%22">Zhao R</searchLink>; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. z_ray1979@126.com.; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. z_ray1979@126.com.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. p.yang@vip.163.com.; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. p.yang@vip.163.com.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. liu118@vip.163.com.; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. liu118@vip.163.com.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China. zxg2008vip@163.com.; Jiangxi Province Key Laboratory of Neurological Diseases, Nanchang, PR China. zxg2008vip@163.com.; Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, 330000, PR China. zxg2008vip@163.com.; Jiangxi Clinical Medical Research Center of Nervous System Diseases, Nanchang, Jiangxi Province, 330000, PR China. zxg2008vip@163.com.; Jiangxi Key Laboratory of Neurological Tumors and Cerebrovascular Diseases; Jiangxi Health Commission Key Laboratory of Neurological Medicine, Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330006, China. zxg2008vip@163.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13063-026-09716-1
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        Text: English
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      – TitleFull: Early lumbar drainage plus intrathecal urokinase in severe aneurysmal subarachnoid hemorrhage: the LD-ITUK randomized controlled trial protocol.
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              Text: 2026 Apr 13
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