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Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth.

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Title: Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth.
Authors: Lorente-Macías Á; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K., Mok J; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K., Dawson JC; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K., Juan-Albuquerque A; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K., Carragher NO; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K., Frame MC; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K., Unciti-Broceta A; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9680-9712. Date of Electronic Publication: 2026 Apr 12.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth.
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  Data: <searchLink fieldCode="AU" term="%22Lorente-Macías+Á%22">Lorente-Macías Á</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.<br /><searchLink fieldCode="AU" term="%22Mok+J%22">Mok J</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.<br /><searchLink fieldCode="AU" term="%22Dawson+JC%22">Dawson JC</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.<br /><searchLink fieldCode="AU" term="%22Juan-Albuquerque+A%22">Juan-Albuquerque A</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.<br /><searchLink fieldCode="AU" term="%22Carragher+NO%22">Carragher NO</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.<br /><searchLink fieldCode="AU" term="%22Frame+MC%22">Frame MC</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.<br /><searchLink fieldCode="AU" term="%22Unciti-Broceta+A%22">Unciti-Broceta A</searchLink>; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, U.K.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 9680-9712. <i>Date of Electronic Publication: </i>2026 Apr 12.
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        Value: 10.1021/acs.jmedchem.6c00541
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      – TitleFull: Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth.
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              Text: 2026 Apr 23
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