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Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.

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Title: Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.
Authors: Qian X; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yue WL; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore, Singapore., Ng KK; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Leong RLF; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ji F; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Venketasubramanian N; Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore., Hilal S; Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chen C; Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chee MWL; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Bassett DS; Departments of Physics & Astronomy, Bioengineering, Electrical & Systems Engineering, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Zhou JH; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore, Singapore.; Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.; Department of Medicine, Healthy Longevity & Human Potential TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Source: PLoS biology [PLoS Biol] 2026 Apr 13; Vol. 24 (4), pp. e3003738. Date of Electronic Publication: 2026 Apr 13 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.
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  Data: <searchLink fieldCode="AU" term="%22Qian+X%22">Qian X</searchLink>; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yue+WL%22">Yue WL</searchLink>; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+KK%22">Ng KK</searchLink>; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Leong+RLF%22">Leong RLF</searchLink>; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ji+F%22">Ji F</searchLink>; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Venketasubramanian+N%22">Venketasubramanian N</searchLink>; Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hilal+S%22">Hilal S</searchLink>; Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chee+MWL%22">Chee MWL</searchLink>; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Bassett+DS%22">Bassett DS</searchLink>; Departments of Physics & Astronomy, Bioengineering, Electrical & Systems Engineering, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhou+JH%22">Zhou JH</searchLink>; Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Integrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore, Singapore.; Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.; Department of Medicine, Healthy Longevity & Human Potential TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
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  Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2026 Apr 13; Vol. 24 (4), pp. e3003738. <i>Date of Electronic Publication: </i>2026 Apr 13 (<i>Print Publication: </i>2026).
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