Bedside model-informed precision dosing of vancomycin in severely ill neonates and children in Belgium (the BENEFICIAL trial): a multicentre, randomised controlled trial.
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| Title: | Bedside model-informed precision dosing of vancomycin in severely ill neonates and children in Belgium (the BENEFICIAL trial): a multicentre, randomised controlled trial. |
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| Authors: | De Cock PA; Faculty of Medicine and Health Sciences, Department of Basic and Applied Medical Sciences, Ghent Precision Dosing Unit, Ghent University and Department of Pharmacy, Ghent University Hospital, Ghent, Belgium. Electronic address: pieter.decock@uzgent.be., Colman R; Faculty of Medicine and Health Sciences, Biostatistics Unit, Ghent University, Ghent, Belgium., Smits A; Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Piersigilli F; Department of Neonatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium., Renard M; Department of Paediatric Haemato-Oncology, University Hospitals Leuven, Leuven, Belgium., Van Damme A; Department of Pediatric Haematology and Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium., Clarysse A; Department of Neonatal Intensive Care, AZ, Sint-Jan Bruges, Bruges, Belgium., Dhont E; Pediatric Intensive Care Unit, Department of Intensive Care Medicine, Ghent University Hospital & Faculty of Medicine and Health Sciences, Department of Basic and Applied Medical Sciences, Ghent Precision Dosing Unit, Ghent University Ghent, Belgium., Vanhaesebrouck S; Department of Neonatal Intensive Care, Ghent University Hospital, Ghent, Belgium., Bordon V; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium., Boland L; Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium., De Wilde B; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium., Amza A; Department of Emergency Medicine, Ghent University Hospital, Ghent, Belgium., Vanlanduyt L; Health, Innovation and Research Institute, Ghent University Hospital, Ghent, Belgium., Nguyen TVA; Department of Basic and Applied Medical Sciences, Ghent Precision Dosing Unit, Ghent University and Department of Pharmacy, Ghent University Hospital, Ghent, Belgium., Cools F; Department of Neonatology, Brussels University Hospital, Brussels, Belgium., van der Werff Ten Bosch J; Department of Paediatric Haemato-Oncology, Brussel University Hospital, Brussels, Belgium., Vens D; University Children's Hospital Reine Fabiola, Department of Pediatric Intensive Care, Brussels, Belgium., Derriks F; Department of Neonatology, Brussels University Hospital, Brussels, Belgium; Department of Neonatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium., Houtekie L; Department of Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium., Mauel R; Department of Pediatric Intensive Care, Brussels University Hospital, Brussels, Belgium., Van der Linden D; Paediatric Infectious Diseases Unit, Specialized Paediatrics Service, Department of Paediatrics, Cliniques universitaires Saint-Luc, Brussels, Belgium., Schelstraete P; Department of Pediatric Infectious Diseases, Ghent University Hospital, Ghent, Belgium. |
| Corporate Authors: | BENEFICIAL study group |
| Source: | The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2026 Jun; Vol. 10 (6), pp. 406-417. Date of Electronic Publication: 2026 Apr 10. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Pragmatic Clinical Trial; Equivalence Trial |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101712925 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-4650 (Electronic) Linking ISSN: 23524642 NLM ISO Abbreviation: Lancet Child Adolesc Health Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41974145 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bedside model-informed precision dosing of vancomycin in severely ill neonates and children in Belgium (the BENEFICIAL trial): a multicentre, randomised controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22De+Cock+PA%22">De Cock PA</searchLink>; Faculty of Medicine and Health Sciences, Department of Basic and Applied Medical Sciences, Ghent Precision Dosing Unit, Ghent University and Department of Pharmacy, Ghent University Hospital, Ghent, Belgium. Electronic address: pieter.decock@uzgent.be.<br /><searchLink fieldCode="AU" term="%22Colman+R%22">Colman R</searchLink>; Faculty of Medicine and Health Sciences, Biostatistics Unit, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Smits+A%22">Smits A</searchLink>; Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Piersigilli+F%22">Piersigilli F</searchLink>; Department of Neonatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Renard+M%22">Renard M</searchLink>; Department of Paediatric Haemato-Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Damme+A%22">Van Damme A</searchLink>; Department of Pediatric Haematology and Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Clarysse+A%22">Clarysse A</searchLink>; Department of Neonatal Intensive Care, AZ, Sint-Jan Bruges, Bruges, Belgium.<br /><searchLink fieldCode="AU" term="%22Dhont+E%22">Dhont E</searchLink>; Pediatric Intensive Care Unit, Department of Intensive Care Medicine, Ghent University Hospital & Faculty of Medicine and Health Sciences, Department of Basic and Applied Medical Sciences, Ghent Precision Dosing Unit, Ghent University Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanhaesebrouck+S%22">Vanhaesebrouck S</searchLink>; Department of Neonatal Intensive Care, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Bordon+V%22">Bordon V</searchLink>; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Boland+L%22">Boland L</searchLink>; Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Wilde+B%22">De Wilde B</searchLink>; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Amza+A%22">Amza A</searchLink>; Department of Emergency Medicine, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanlanduyt+L%22">Vanlanduyt L</searchLink>; Health, Innovation and Research Institute, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Nguyen+TVA%22">Nguyen TVA</searchLink>; Department of Basic and Applied Medical Sciences, Ghent Precision Dosing Unit, Ghent University and Department of Pharmacy, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Cools+F%22">Cools F</searchLink>; Department of Neonatology, Brussels University Hospital, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22van+der+Werff+Ten+Bosch+J%22">van der Werff Ten Bosch J</searchLink>; Department of Paediatric Haemato-Oncology, Brussel University Hospital, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Vens+D%22">Vens D</searchLink>; University Children's Hospital Reine Fabiola, Department of Pediatric Intensive Care, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Derriks+F%22">Derriks F</searchLink>; Department of Neonatology, Brussels University Hospital, Brussels, Belgium; Department of Neonatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Houtekie+L%22">Houtekie L</searchLink>; Department of Pediatric Intensive Care Unit, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Mauel+R%22">Mauel R</searchLink>; Department of Pediatric Intensive Care, Brussels University Hospital, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+der+Linden+D%22">Van der Linden D</searchLink>; Paediatric Infectious Diseases Unit, Specialized Paediatrics Service, Department of Paediatrics, Cliniques universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Schelstraete+P%22">Schelstraete P</searchLink>; Department of Pediatric Infectious Diseases, Ghent University Hospital, Ghent, Belgium. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22BENEFICIAL+study+group%22">BENEFICIAL study group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101712925%22">The Lancet. Child & adolescent health</searchLink> [Lancet Child Adolesc Health] 2026 Jun; Vol. 10 (6), pp. 406-417. <i>Date of Electronic Publication: </i>2026 Apr 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Multicenter Study; Randomized Controlled Trial; Pragmatic Clinical Trial; Equivalence Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101712925 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-4650 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223524642%22">23524642 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Child Adolesc Health <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41974145 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S2352-4642(25)00385-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 406 Titles: – TitleFull: Bedside model-informed precision dosing of vancomycin in severely ill neonates and children in Belgium (the BENEFICIAL trial): a multicentre, randomised controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: De Cock PA – PersonEntity: Name: NameFull: Colman R – PersonEntity: Name: NameFull: Smits A – PersonEntity: Name: NameFull: Piersigilli F – PersonEntity: Name: NameFull: Renard M – PersonEntity: Name: NameFull: Van Damme A – PersonEntity: Name: NameFull: Clarysse A – PersonEntity: Name: NameFull: Dhont E – PersonEntity: Name: NameFull: Vanhaesebrouck S – PersonEntity: Name: NameFull: Bordon V – PersonEntity: Name: NameFull: Boland L – PersonEntity: Name: NameFull: De Wilde B – PersonEntity: Name: NameFull: Amza A – PersonEntity: Name: NameFull: Vanlanduyt L – PersonEntity: Name: NameFull: Nguyen TVA – PersonEntity: Name: NameFull: Cools F – PersonEntity: Name: NameFull: van der Werff Ten Bosch J – PersonEntity: Name: NameFull: Vens D – PersonEntity: Name: NameFull: Derriks F – PersonEntity: Name: NameFull: Houtekie L – PersonEntity: Name: NameFull: Mauel R – PersonEntity: Name: NameFull: Van der Linden D – PersonEntity: Name: NameFull: Schelstraete P IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2352-4650 Numbering: – Type: volume Value: 10 – Type: issue Value: 6 Titles: – TitleFull: The Lancet. Child & adolescent health Type: main |
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