Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects against Stress-Induced Reinstatement in Both Male and Female Rats.

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Title:	Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects against Stress-Induced Reinstatement in Both Male and Female Rats.
Authors:	Higginbotham JA; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Dearman JJ; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Pujol M; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Teich R; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Maqbool H; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Moron JA; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110 Jmoron-concepcion@wustl.edu.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.; Departments of Neuroscience, Washington University in St. Louis, St. Louis, Missouri 63110.; Psychiatry, Washington University in St. Louis, St. Louis, Missouri 63110.
Source:	ENeuro [eNeuro] 2026 Apr 20; Vol. 13 (4). Date of Electronic Publication: 2026 Apr 20 (Print Publication: 2026).
Publication Type:	Journal Article
Journal Info:	Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	2373-2822
DOI:	10.1523/ENEURO.0447-25.2026