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Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects against Stress-Induced Reinstatement in Both Male and Female Rats.

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Title: Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects against Stress-Induced Reinstatement in Both Male and Female Rats.
Authors: Higginbotham JA; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Dearman JJ; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Pujol M; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Teich R; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Maqbool H; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110., Moron JA; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110 Jmoron-concepcion@wustl.edu.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.; Departments of Neuroscience, Washington University in St. Louis, St. Louis, Missouri 63110.; Psychiatry, Washington University in St. Louis, St. Louis, Missouri 63110.
Source: ENeuro [eNeuro] 2026 Apr 20; Vol. 13 (4). Date of Electronic Publication: 2026 Apr 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE
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  Data: Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects against Stress-Induced Reinstatement in Both Male and Female Rats.
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  Data: <searchLink fieldCode="AU" term="%22Higginbotham+JA%22">Higginbotham JA</searchLink>; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.<br /><searchLink fieldCode="AU" term="%22Dearman+JJ%22">Dearman JJ</searchLink>; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.<br /><searchLink fieldCode="AU" term="%22Pujol+M%22">Pujol M</searchLink>; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.<br /><searchLink fieldCode="AU" term="%22Teich+R%22">Teich R</searchLink>; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.<br /><searchLink fieldCode="AU" term="%22Maqbool+H%22">Maqbool H</searchLink>; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.<br /><searchLink fieldCode="AU" term="%22Moron+JA%22">Moron JA</searchLink>; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110 Jmoron-concepcion@wustl.edu.; Pain Center, Washington University in St. Louis, St. Louis, Missouri 63110.; School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.; Departments of Neuroscience, Washington University in St. Louis, St. Louis, Missouri 63110.; Psychiatry, Washington University in St. Louis, St. Louis, Missouri 63110.
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  Data: <searchLink fieldCode="JN" term="%22101647362%22">ENeuro</searchLink> [eNeuro] 2026 Apr 20; Vol. 13 (4). <i>Date of Electronic Publication: </i>2026 Apr 20 (<i>Print Publication: </i>2026).
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        Value: 10.1523/ENEURO.0447-25.2026
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