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Long term administration of selective NMDA GluN2B receptor blocker Ro25-6981 attenuates neurodegeneration in mouse model of spinocerebellar ataxia type 1 (SCA1).

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Title: Long term administration of selective NMDA GluN2B receptor blocker Ro25-6981 attenuates neurodegeneration in mouse model of spinocerebellar ataxia type 1 (SCA1).
Authors: Belozor OS; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia., Mileiko AG; Scientific Research Institute of Medical Problems of North - a separate division of Federal Research Center 'Krasnoyarsk Science Center' of the Siberian Branch of the Russian Academy of Science, Krasnoyarsk, Russia., Mosina LD; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.; Siberian Federal University, Krasnoyarsk, Russia., Mikhailov IG; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.; Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Federal Research Center 'Krasnoyarsk Science Center SB RAS', Krasnoyarsk, Russia., Mikhailova MS; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia., Khilazeva ED; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia., Ox DA; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.; Siberian Federal University, Krasnoyarsk, Russia., Grinev ES; Siberian Federal University, Krasnoyarsk, Russia.; Sirius University of Science and Technology, Sochi, Russia., Boitsova EB; Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russia., Shuvaev AN; Siberian Federal University, Krasnoyarsk, Russia., Teschemacher AG; School of Psychology and Neuroscience, University of Bristol, Bristol, UK., Kasparov S; School of Psychology and Neuroscience, University of Bristol, Bristol, UK., Shuvaev AN; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia. shuvaevan@krasgmu.ru.
Source: Cell death discovery [Cell Death Discov] 2026 Apr 13; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Long term administration of selective NMDA GluN2B receptor blocker Ro25-6981 attenuates neurodegeneration in mouse model of spinocerebellar ataxia type 1 (SCA1).
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  Data: <searchLink fieldCode="AU" term="%22Belozor+OS%22">Belozor OS</searchLink>; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Mileiko+AG%22">Mileiko AG</searchLink>; Scientific Research Institute of Medical Problems of North - a separate division of Federal Research Center 'Krasnoyarsk Science Center' of the Siberian Branch of the Russian Academy of Science, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Mosina+LD%22">Mosina LD</searchLink>; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.; Siberian Federal University, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Mikhailov+IG%22">Mikhailov IG</searchLink>; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.; Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Federal Research Center 'Krasnoyarsk Science Center SB RAS', Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Mikhailova+MS%22">Mikhailova MS</searchLink>; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Khilazeva+ED%22">Khilazeva ED</searchLink>; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Ox+DA%22">Ox DA</searchLink>; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.; Siberian Federal University, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Grinev+ES%22">Grinev ES</searchLink>; Siberian Federal University, Krasnoyarsk, Russia.; Sirius University of Science and Technology, Sochi, Russia.<br /><searchLink fieldCode="AU" term="%22Boitsova+EB%22">Boitsova EB</searchLink>; Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Shuvaev+AN%22">Shuvaev AN</searchLink>; Siberian Federal University, Krasnoyarsk, Russia.<br /><searchLink fieldCode="AU" term="%22Teschemacher+AG%22">Teschemacher AG</searchLink>; School of Psychology and Neuroscience, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Kasparov+S%22">Kasparov S</searchLink>; School of Psychology and Neuroscience, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Shuvaev+AN%22">Shuvaev AN</searchLink>; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia. shuvaevan@krasgmu.ru.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Apr 13; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Apr 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41420-026-03120-z
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              Text: 2026 Apr 13
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