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Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis.

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Title: Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis.
Authors: Silcocks M; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia. m.silcocks@unimelb.edu.au., Lingford JP; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Cheung CY; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand., Jowsey WJ; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand., McCall RM; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA., Rae CD; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA., Harold LK; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand., Edwards D; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Pepper-Tunick E; Institute for Systems Biology, Seattle, WA, USA., Neville SL; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Maher MJ; School of Chemistry, Department of Biochemistry and Pharmacology and the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia., Canalda-Baltrons A; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia., Chang X; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore., Thai PVK; Tam Tri Sai Gon Hospital, District 12, Ho Chi Minh City, Vietnam., Holt KE; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK., Baliga NS; Institute for Systems Biology, Seattle, WA, USA., Cook GM; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Hawn TR; Department of Medicine, University of Washington, Seattle, WA, USA., Thuong NTT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Caws M; Liverpool School of Tropical Medicine, Liverpool, UK.; Birat Nepal Medical Trust, Kathmandu, Nepal., Greening C; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., McDevitt CA; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Cox JS; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA., McNeil MB; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Dunstan SJ; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia. sarah.dunstan@unimelb.edu.au.
Source: Nature communications [Nat Commun] 2026 Apr 13; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis.
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  Data: <searchLink fieldCode="AU" term="%22Silcocks+M%22">Silcocks M</searchLink>; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia. m.silcocks@unimelb.edu.au.<br /><searchLink fieldCode="AU" term="%22Lingford+JP%22">Lingford JP</searchLink>; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cheung+CY%22">Cheung CY</searchLink>; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Jowsey+WJ%22">Jowsey WJ</searchLink>; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22McCall+RM%22">McCall RM</searchLink>; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rae+CD%22">Rae CD</searchLink>; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Harold+LK%22">Harold LK</searchLink>; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Edwards+D%22">Edwards D</searchLink>; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pepper-Tunick+E%22">Pepper-Tunick E</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Neville+SL%22">Neville SL</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Maher+MJ%22">Maher MJ</searchLink>; School of Chemistry, Department of Biochemistry and Pharmacology and the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Canalda-Baltrons+A%22">Canalda-Baltrons A</searchLink>; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chang+X%22">Chang X</searchLink>; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Thai+PVK%22">Thai PVK</searchLink>; Tam Tri Sai Gon Hospital, District 12, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Holt+KE%22">Holt KE</searchLink>; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Baliga+NS%22">Baliga NS</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cook+GM%22">Cook GM</searchLink>; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Hawn+TR%22">Hawn TR</searchLink>; Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Thuong+NTT%22">Thuong NTT</searchLink>; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Caws+M%22">Caws M</searchLink>; Liverpool School of Tropical Medicine, Liverpool, UK.; Birat Nepal Medical Trust, Kathmandu, Nepal.<br /><searchLink fieldCode="AU" term="%22Greening+C%22">Greening C</searchLink>; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22McDevitt+CA%22">McDevitt CA</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cox+JS%22">Cox JS</searchLink>; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22McNeil+MB%22">McNeil MB</searchLink>; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.; Department of Biochemistry, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Dunstan+SJ%22">Dunstan SJ</searchLink>; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia. sarah.dunstan@unimelb.edu.au.
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