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Herpes simplex virus 1 harboring poly(T) DNA sequences as a key ligand for AIM2 inflammasome activation and host defense.

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Title: Herpes simplex virus 1 harboring poly(T) DNA sequences as a key ligand for AIM2 inflammasome activation and host defense.
Authors: Oh S; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Oh J; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Im K; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea., Kim TH; Department of Biomedicine & Drug Development, Jeju National University Graduate School, Jeju, Republic of Korea., Lee J; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Shin K; Department of Microbiology and Immunology, Jeju National University College of Medicine, Jeju, Republic of Korea.; Jeju Research Center for Natural Medicine, Jeju National University Core Research Institute, Jeju, Republic of Korea., Mariam N; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea., Seok C; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea., Park J; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Yu G; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Kim H; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Kim S; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Shin S; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Gil J; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Park S; Division of Acute Viral Disease, Center for Emerging Virus Research, National Institute of Infectious Diseases, National Institute of Health, Cheongju, Republic of Korea., Chung YS; Division of High-Risk Pathogens, Department of Laboratory Diagnosis and Analysis, Korea Disease Control and Prevention Agency, KDCA, Cheongju, Republic of Korea., Kim D; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea., Choi YK; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea. choiki55@ibs.re.kr., Kim ET; Department of Biomedicine & Drug Development, Jeju National University Graduate School, Jeju, Republic of Korea. tae@jejunu.ac.kr.; Department of Microbiology and Immunology, Jeju National University College of Medicine, Jeju, Republic of Korea. tae@jejunu.ac.kr.; Jeju Research Center for Natural Medicine, Jeju National University Core Research Institute, Jeju, Republic of Korea. tae@jejunu.ac.kr., Lee JS; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea. joosang.lee@skku.edu.; Department of Digital Health, Samsung Advanced Institute of Health Science and Technology and Department of Artificial Intelligence, Sungkyunkwan University, Suwon, Republic of Korea. joosang.lee@skku.edu., Lee S; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea. sangjoon.lee@unist.ac.kr.; Graduate School of Health Science and Technology, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea. sangjoon.lee@unist.ac.kr.
Source: Nature communications [Nat Commun] 2026 Apr 13; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Herpes simplex virus 1 harboring poly(T) DNA sequences as a key ligand for AIM2 inflammasome activation and host defense.
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  Data: <searchLink fieldCode="AU" term="%22Oh+S%22">Oh S</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+J%22">Oh J</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Im+K%22">Im K</searchLink>; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+TH%22">Kim TH</searchLink>; Department of Biomedicine & Drug Development, Jeju National University Graduate School, Jeju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shin+K%22">Shin K</searchLink>; Department of Microbiology and Immunology, Jeju National University College of Medicine, Jeju, Republic of Korea.; Jeju Research Center for Natural Medicine, Jeju National University Core Research Institute, Jeju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Mariam+N%22">Mariam N</searchLink>; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Seok+C%22">Seok C</searchLink>; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yu+G%22">Yu G</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shin+S%22">Shin S</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Gil+J%22">Gil J</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Division of Acute Viral Disease, Center for Emerging Virus Research, National Institute of Infectious Diseases, National Institute of Health, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chung+YS%22">Chung YS</searchLink>; Division of High-Risk Pathogens, Department of Laboratory Diagnosis and Analysis, Korea Disease Control and Prevention Agency, KDCA, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+YK%22">Choi YK</searchLink>; Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea. choiki55@ibs.re.kr.<br /><searchLink fieldCode="AU" term="%22Kim+ET%22">Kim ET</searchLink>; Department of Biomedicine & Drug Development, Jeju National University Graduate School, Jeju, Republic of Korea. tae@jejunu.ac.kr.; Department of Microbiology and Immunology, Jeju National University College of Medicine, Jeju, Republic of Korea. tae@jejunu.ac.kr.; Jeju Research Center for Natural Medicine, Jeju National University Core Research Institute, Jeju, Republic of Korea. tae@jejunu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Lee+JS%22">Lee JS</searchLink>; Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea. joosang.lee@skku.edu.; Department of Digital Health, Samsung Advanced Institute of Health Science and Technology and Department of Artificial Intelligence, Sungkyunkwan University, Suwon, Republic of Korea. joosang.lee@skku.edu.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Biological Science, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea. sangjoon.lee@unist.ac.kr.; Graduate School of Health Science and Technology, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea. sangjoon.lee@unist.ac.kr.
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              Text: 2026 Apr 13
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