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Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.

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Title: Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
Authors: Mishra M; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA., Kim HH; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA., Youm YH; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA., Gonzalez-Hurtado E; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA., Zaitsev K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Dlugos T; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA., Shchukina I; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Gliniak C; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ravussin E; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Mohanty S; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Shaw AC; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA., Scherer PE; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Dixit VD; Department of Pathology, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.
Source: Nature aging [Nat Aging] 2026 May; Vol. 6 (5), pp. 1064-1078. Date of Electronic Publication: 2026 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mishra+M%22">Mishra M</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kim+HH%22">Kim HH</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Youm+YH%22">Youm YH</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Hurtado+E%22">Gonzalez-Hurtado E</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Zaitsev+K%22">Zaitsev K</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Dlugos+T%22">Dlugos T</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Shchukina+I%22">Shchukina I</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gliniak+C%22">Gliniak C</searchLink>; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ravussin+E%22">Ravussin E</searchLink>; Pennington Biomedical Research Center, Baton Rouge, LA, USA.<br /><searchLink fieldCode="AU" term="%22Mohanty+S%22">Mohanty S</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+AC%22">Shaw AC</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Scherer+PE%22">Scherer PE</searchLink>; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Artyomov+MN%22">Artyomov MN</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Dixit+VD%22">Dixit VD</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA. vishwa.dixit@yale.edu.
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