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Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer.

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Title: Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer.
Authors: Klinkhammer H; Institute for Medical Biometry and Statistics, Philipps-University of Marburg, Marburg, Germany.; Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany., Spier I; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Bonn, Germany., Perne C; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany., Hoffmann P; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany., Büttner R; Institute of Pathology, Cologne University Hospital, Cologne, Germany., Schröck E; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Redler S; Institute of Human Genetics, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany., Jahn A; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Franke M; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Möslein G; Surgical Center for Hereditary Tumors, BETHESDA Hospital Duisburg, Academic Hospital University of Düsseldorf, Duisburg, Germany., Kloor M; Department of Applied Tumor Biology, Heidelberg University Hospital, Heidelberg, Germany., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany., Vangala D; Outpatient Center for Hematology and Oncology, Cancer Center Bochum-Herne, Bochum, Germany.; Department of Human Genetics, Medical Faculty, Ruhr-University Bochum, Bochum, Germany., Nguyen HP; Department of Human Genetics, Medical Faculty, Ruhr-University Bochum, Bochum, Germany., Forstner AJ; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany., Steinke-Lange V; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.; MGZ-Medical Genetics Center, Munich, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Munich, Germany., Holinski-Feder E; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.; MGZ-Medical Genetics Center, Munich, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Munich, Germany., Hüneburg R; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Bonn, Germany.; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Maj C; Centre for Human Genetics, University of Marburg, Marburg, Germany., Engel C; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany., Mayr A; Institute for Medical Biometry and Statistics, Philipps-University of Marburg, Marburg, Germany., Aretz S; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Bonn, Germany.
Source: JNCI cancer spectrum [JNCI Cancer Spectr] 2026 May 09; Vol. 10 (3).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101721827 Publication Model: Print Cited Medium: Internet ISSN: 2515-5091 (Electronic) Linking ISSN: 25155091 NLM ISO Abbreviation: JNCI Cancer Spectr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Klinkhammer+H%22">Klinkhammer H</searchLink>; Institute for Medical Biometry and Statistics, Philipps-University of Marburg, Marburg, Germany.; Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Spier+I%22">Spier I</searchLink>; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Perne+C%22">Perne C</searchLink>; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+P%22">Hoffmann P</searchLink>; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Büttner+R%22">Büttner R</searchLink>; Institute of Pathology, Cologne University Hospital, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Schröck+E%22">Schröck E</searchLink>; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Redler+S%22">Redler S</searchLink>; Institute of Human Genetics, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Jahn+A%22">Jahn A</searchLink>; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Franke+M%22">Franke M</searchLink>; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Dresden, Germany.; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Möslein+G%22">Möslein G</searchLink>; Surgical Center for Hereditary Tumors, BETHESDA Hospital Duisburg, Academic Hospital University of Düsseldorf, Duisburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kloor+M%22">Kloor M</searchLink>; Department of Applied Tumor Biology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+B%22">Schmidt B</searchLink>; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Vangala+D%22">Vangala D</searchLink>; Outpatient Center for Hematology and Oncology, Cancer Center Bochum-Herne, Bochum, Germany.; Department of Human Genetics, Medical Faculty, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Nguyen+HP%22">Nguyen HP</searchLink>; Department of Human Genetics, Medical Faculty, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Forstner+AJ%22">Forstner AJ</searchLink>; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Steinke-Lange+V%22">Steinke-Lange V</searchLink>; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.; MGZ-Medical Genetics Center, Munich, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Holinski-Feder+E%22">Holinski-Feder E</searchLink>; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.; MGZ-Medical Genetics Center, Munich, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hüneburg+R%22">Hüneburg R</searchLink>; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Bonn, Germany.; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Maj+C%22">Maj C</searchLink>; Centre for Human Genetics, University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Engel+C%22">Engel C</searchLink>; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Mayr+A%22">Mayr A</searchLink>; Institute for Medical Biometry and Statistics, Philipps-University of Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Aretz+S%22">Aretz S</searchLink>; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany.; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany.; Hereditary Cancer Syndrome Center, ERN GENTURIS, Bonn, Germany.
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