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RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence.

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Title: RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence.
Authors: Cortolezzis Y; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy., Tolotto V; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy., Triboli L; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy., Picco R; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy., Soler MA; Dipartimento di Scienze Matematiche, Informatiche e Fisiche, University of Udine, Via delle Scienze 206, 33100 Udine, Italy.; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy., Fortuna S; Dipartimento di Scienze Matematiche, Informatiche e Fisiche, University of Udine, Via delle Scienze 206, 33100 Udine, Italy., Bettin G; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy., D'Este F; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy., Carlassara E; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy., Magris G; Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, 33100 Udine, Italy., Miller KM; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute, GA 30307 Atlanta, United States., Angelini A; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy., Xodo LE; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy., Di Giorgio E; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Apr 13; Vol. 54 (7).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence.
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  Data: <searchLink fieldCode="AU" term="%22Cortolezzis+Y%22">Cortolezzis Y</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Tolotto+V%22">Tolotto V</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Triboli+L%22">Triboli L</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Picco+R%22">Picco R</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Soler+MA%22">Soler MA</searchLink>; Dipartimento di Scienze Matematiche, Informatiche e Fisiche, University of Udine, Via delle Scienze 206, 33100 Udine, Italy.; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Fortuna+S%22">Fortuna S</searchLink>; Dipartimento di Scienze Matematiche, Informatiche e Fisiche, University of Udine, Via delle Scienze 206, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Bettin+G%22">Bettin G</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22D'Este+F%22">D'Este F</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Carlassara+E%22">Carlassara E</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Magris+G%22">Magris G</searchLink>; Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Miller+KM%22">Miller KM</searchLink>; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute, GA 30307 Atlanta, United States.<br /><searchLink fieldCode="AU" term="%22Angelini+A%22">Angelini A</searchLink>; Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Xodo+LE%22">Xodo LE</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Giorgio+E%22">Di Giorgio E</searchLink>; Laboratory of Biochemistry, Department of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy.
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