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Low IgM Levels in Adult IEI: Classification Challenges and Clinical Implications.

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Title: Low IgM Levels in Adult IEI: Classification Challenges and Clinical Implications.
Authors: Gumusburun R; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey. reyhangumusburun@gmail.com., Okan K; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Akdaglı E; Department of Internal Medicine, Ege University Faculty of Medicine, Izmir, Turkey., Yıldırım O; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Akten HS; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Inan S; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey. drsineminan@gmail.com., Demiroglu G; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Galata Z; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Kural RF; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Aytac H; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Ozeki Y; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Aslan E; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Ates U; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Kırdok K; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Senturk MIT; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Unal NG; Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Ege University, Izmir, Turkey., Demir D; Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey., Soyer N; Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ege University, Izmir, Turkey. drakadnur@yahoo.com., Soylu M; Faculty of Medicine, Department of Microbiology, Ege University, Izmir, Turkey., Uysal FE; Faculty of Medicine, Department of Pulmonary Diseases, Ege University, Izmir, Turkey., Aykut A; Faculty of Medicine, Department of Medical Genetics, Ege University, Izmir, Turkey., Durmaz A; Faculty of Medicine, Department of Medical Genetics, Ege University, Izmir, Turkey. asudealpman@gmail.com., Dalgıc CT; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey., Sin AZ; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey. aytulsin@yahoo.com., Ardeniz O; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.
Source: Journal of clinical immunology [J Clin Immunol] 2026 Apr 14; Vol. 46 (1). Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8102137 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2592 (Electronic) Linking ISSN: 02719142 NLM ISO Abbreviation: J Clin Immunol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gumusburun+R%22">Gumusburun R</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey. reyhangumusburun@gmail.com.<br /><searchLink fieldCode="AU" term="%22Okan+K%22">Okan K</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Akdaglı+E%22">Akdaglı E</searchLink>; Department of Internal Medicine, Ege University Faculty of Medicine, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Yıldırım+O%22">Yıldırım O</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Akten+HS%22">Akten HS</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Inan+S%22">Inan S</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey. drsineminan@gmail.com.<br /><searchLink fieldCode="AU" term="%22Demiroglu+G%22">Demiroglu G</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Galata+Z%22">Galata Z</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Kural+RF%22">Kural RF</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Aytac+H%22">Aytac H</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Ozeki+Y%22">Ozeki Y</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Aslan+E%22">Aslan E</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Ates+U%22">Ates U</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Kırdok+K%22">Kırdok K</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Senturk+MIT%22">Senturk MIT</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Unal+NG%22">Unal NG</searchLink>; Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Ege University, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Demir+D%22">Demir D</searchLink>; Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Soyer+N%22">Soyer N</searchLink>; Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ege University, Izmir, Turkey. drakadnur@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Soylu+M%22">Soylu M</searchLink>; Faculty of Medicine, Department of Microbiology, Ege University, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Uysal+FE%22">Uysal FE</searchLink>; Faculty of Medicine, Department of Pulmonary Diseases, Ege University, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Aykut+A%22">Aykut A</searchLink>; Faculty of Medicine, Department of Medical Genetics, Ege University, Izmir, Turkey.<br /><searchLink fieldCode="AU" term="%22Durmaz+A%22">Durmaz A</searchLink>; Faculty of Medicine, Department of Medical Genetics, Ege University, Izmir, Turkey. asudealpman@gmail.com.<br /><searchLink fieldCode="AU" term="%22Dalgıc+CT%22">Dalgıc CT</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Sin+AZ%22">Sin AZ</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey. aytulsin@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Ardeniz+O%22">Ardeniz O</searchLink>; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, Izmir, Türkiye, Turkey.
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