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Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons.

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Title: Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons.
Authors: Vargas JNS; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK., Brown AL; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Sun K; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK., Hagemann C; Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RT, UK.; UK Dementia Research Institute, King's College London, London NW1 3BT, UK.; Francis Crick Institute, London NW1 1AT, UK., Geary B; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH Scotland, UK., Villarroel-Campos D; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK., Bryce-Smith S; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Zanovello M; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Lombardo M; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Majewski S; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; Francis Crick Institute, London NW1 1AT, UK., Tosolini A; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Secrier M; Department of Genetics, Evolution, and Environment, UCL Genetics Institute, University College London, London WC1E 6BT, UK., Keuss MJ; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Serio A; Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RT, UK.; UK Dementia Research Institute, King's College London, London NW1 3BT, UK.; Francis Crick Institute, London NW1 1AT, UK., Sleigh JN; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK., Fratta P; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Schiavo G; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK.
Source: Science signaling [Sci Signal] 2026 Apr 14; Vol. 19 (933), pp. eadx6752. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
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  Data: Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons.
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  Data: <searchLink fieldCode="AU" term="%22Vargas+JNS%22">Vargas JNS</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK.<br /><searchLink fieldCode="AU" term="%22Brown+AL%22">Brown AL</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Sun+K%22">Sun K</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK.<br /><searchLink fieldCode="AU" term="%22Hagemann+C%22">Hagemann C</searchLink>; Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RT, UK.; UK Dementia Research Institute, King's College London, London NW1 3BT, UK.; Francis Crick Institute, London NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Geary+B%22">Geary B</searchLink>; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Villarroel-Campos+D%22">Villarroel-Campos D</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK.<br /><searchLink fieldCode="AU" term="%22Bryce-Smith+S%22">Bryce-Smith S</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Zanovello+M%22">Zanovello M</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Lombardo+M%22">Lombardo M</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Majewski+S%22">Majewski S</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; Francis Crick Institute, London NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Tosolini+A%22">Tosolini A</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Secrier+M%22">Secrier M</searchLink>; Department of Genetics, Evolution, and Environment, UCL Genetics Institute, University College London, London WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Keuss+MJ%22">Keuss MJ</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Serio+A%22">Serio A</searchLink>; Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RT, UK.; UK Dementia Research Institute, King's College London, London NW1 3BT, UK.; Francis Crick Institute, London NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Sleigh+JN%22">Sleigh JN</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK.<br /><searchLink fieldCode="AU" term="%22Fratta+P%22">Fratta P</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Schiavo+G%22">Schiavo G</searchLink>; Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; UK Dementia Research Institute, University College London, London NW1 3BT, UK.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2026 Apr 14; Vol. 19 (933), pp. eadx6752. <i>Date of Electronic Publication: </i>2026 Apr 14.
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