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Kinsenoside Targets IDH1 to Restore Microglial Immune-Metabolic Homeostasis for Alzheimer's Disease Therapy.

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Title: Kinsenoside Targets IDH1 to Restore Microglial Immune-Metabolic Homeostasis for Alzheimer's Disease Therapy.
Authors: Li Q; The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China., Liao Y; Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.; NHC Key Laboratory of Neurodegenerative diseases (University of South China), Hengyang, China., Zhao YB; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China., Wu H; Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Jin T; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Li S; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Liu Y; School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China., Li P; College of Basic Sciences, College of Basic Sciences, Shanxi Agricultural University, Jinzhong, China., Ouyang S; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China., Li Z; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China., Xia Y; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China., Hua Q; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Pan RY; Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Yuan Z; The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.; NHC Key Laboratory of Neurodegenerative diseases (University of South China), Hengyang, China.; Key Laboratory of Clinical Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, China.; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology, Shanxi University of Chinese Medicine, Jinzhong, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Jun; Vol. 13 (36), pp. e75125. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Kinsenoside Targets IDH1 to Restore Microglial Immune-Metabolic Homeostasis for Alzheimer's Disease Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liao+Y%22">Liao Y</searchLink>; Department of Neurology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.; NHC Key Laboratory of Neurodegenerative diseases (University of South China), Hengyang, China.<br /><searchLink fieldCode="AU" term="%22Zhao+YB%22">Zhao YB</searchLink>; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Jin+T%22">Jin T</searchLink>; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; College of Basic Sciences, College of Basic Sciences, Shanxi Agricultural University, Jinzhong, China.<br /><searchLink fieldCode="AU" term="%22Ouyang+S%22">Ouyang S</searchLink>; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Hua+Q%22">Hua Q</searchLink>; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Pan+RY%22">Pan RY</searchLink>; Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yuan+Z%22">Yuan Z</searchLink>; The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.; NHC Key Laboratory of Neurodegenerative diseases (University of South China), Hengyang, China.; Key Laboratory of Clinical Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, Hebei, China.; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology, Shanxi University of Chinese Medicine, Jinzhong, China.
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        Value: 10.1002/advs.75125
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      – TitleFull: Kinsenoside Targets IDH1 to Restore Microglial Immune-Metabolic Homeostasis for Alzheimer's Disease Therapy.
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              Text: 2026 Jun
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