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Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor.

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Title: Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor.
Authors: Balfe EM; Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania., Torbey A; Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Quebec, Canada., Stepniewski TM; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain; InterAx Biotech AG, Villigen, Switzerland., Zhou Y; Department of Cell Biology, Duke University, Durham, North Carolina., Kohlenbach L; Department of Cell Biology, Duke University, Durham, North Carolina., Sency JA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan., Slosky LM; Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota., Selent J; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain., Barak LS; Department of Cell Biology, Duke University, Durham, North Carolina., Gross JD; Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania; Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania. Electronic address: jdg6119@psu.edu.
Source: Molecular pharmacology [Mol Pharmacol] 2026 Apr; Vol. 108 (4), pp. 100119. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor.
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  Data: <searchLink fieldCode="AU" term="%22Balfe+EM%22">Balfe EM</searchLink>; Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Torbey+A%22">Torbey A</searchLink>; Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Stepniewski+TM%22">Stepniewski TM</searchLink>; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain; InterAx Biotech AG, Villigen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Cell Biology, Duke University, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Kohlenbach+L%22">Kohlenbach L</searchLink>; Department of Cell Biology, Duke University, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Sency+JA%22">Sency JA</searchLink>; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Inoue+A%22">Inoue A</searchLink>; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Slosky+LM%22">Slosky LM</searchLink>; Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Selent+J%22">Selent J</searchLink>; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Barak+LS%22">Barak LS</searchLink>; Department of Cell Biology, Duke University, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Gross+JD%22">Gross JD</searchLink>; Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania; Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania. Electronic address: jdg6119@psu.edu.
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  Data: <searchLink fieldCode="JN" term="%220035623%22">Molecular pharmacology</searchLink> [Mol Pharmacol] 2026 Apr; Vol. 108 (4), pp. 100119. <i>Date of Electronic Publication: </i>2026 Mar 13.
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              Text: 2026 Apr
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