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Potent acridone antimalarial against all three life stages of Plasmodium.

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Title: Potent acridone antimalarial against all three life stages of Plasmodium.
Authors: Kancharla P; Department of Chemistry, Portland State University, Portland, OR, USA. papiredd@pdx.edu., Dodean RA; Department of Chemistry, Portland State University, Portland, OR, USA.; Department of Veterans Affairs Medical Center, Portland, OR, USA., Li Y; Department of Veterans Affairs Medical Center, Portland, OR, USA., Zhang X; Department of Veterans Affairs Medical Center, Portland, OR, USA., Kelly S; Department of Veterans Affairs Medical Center, Portland, OR, USA., Charlton J; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA., Binauhan AJ; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA., Navarrete K; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA., Garcia L; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA., Mu J; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD, USA., Lu J; Lab of Immunogenetics, Structural Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Caridha D; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Madejczyk MS; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Jin X; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Dennis WE; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Kudyba K; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Integrated Pathogen Therapeutics Department, Walter Reed Army Institute of Research, Silver Spring, MD, USA., McEnearney S; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Lee PJ; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Blount C; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., DeLuca J; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Vuong C; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Pannone K; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Dinh HT; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Mdaki K; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Leed S; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Integrated Pathogen Therapeutics Department, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Martin ML; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Pybus BS; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Chin GC; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Chim-Ong A; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Cui L; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Qahash T; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dam, IN, USA., Shoue DA; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dam, IN, USA., Ferdig MT; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dam, IN, USA., Mockenhaupt FP; Institute of International Health, Charité Center for Global Health, Charité-Universitaetsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., van Loon W; Institute of International Health, Charité Center for Global Health, Charité-Universitaetsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Ndoli JM; College of Medicine and Health Sciences, University Teaching Hospital of Butare, University of Rwanda, Huye, Rwanda., Kudyba H; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD, USA., Vega-Rodriguez J; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD, USA., Okitwi M; Infectious Diseases Research Collaboration, Kampala, Uganda., Kreutzfeld O; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Docan C; Biosciences Division, SRI International, Menlo Park, CA, USA., Green C; Biosciences Division, SRI International, Menlo Park, CA, USA., Liu Y; Biosciences Division, SRI International, Menlo Park, CA, USA., Agulay A; Biosciences Division, SRI International, Menlo Park, CA, USA., Mirsalis J; Biosciences Division, SRI International, Menlo Park, CA, USA., Farrell SN; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia., Probst AS; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA., Nilsen A; Department of Veterans Affairs Medical Center, Portland, OR, USA.; Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA., Alday PH; Department of Veterans Affairs Medical Center, Portland, OR, USA., Stone Doggett J; Department of Veterans Affairs Medical Center, Portland, OR, USA.; Department of Medicine, Oregon Health & Science University, Portland, OR, USA., McFadden GI; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia., Goodman CD; School of Biosciences, The University of Melbourne, Parkville, VIC, Australia., Catteruccia F; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Rosenthal PJ; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Riscoe MK; Department of Veterans Affairs Medical Center, Portland, OR, USA.; Department of Microbiology and Molecular Immunology, Oregon Health & Science University, Portland, OR, USA., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA., Roth A; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Integrated Pathogen Therapeutics Department, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Kelly JX; Department of Chemistry, Portland State University, Portland, OR, USA. kellyja@ohsu.edu.; Department of Veterans Affairs Medical Center, Portland, OR, USA. kellyja@ohsu.edu.
Source: Nature communications [Nat Commun] 2026 Apr 14; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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          Dates:
            – D: 14
              M: 04
              Text: 2026 Apr 14
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1