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Blocking ubiquitination of hnRNPA1 maintains the self-renewal of breast cancer stem cells via mutually exclusive splicing of PKM pre-mRNA.

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Title: Blocking ubiquitination of hnRNPA1 maintains the self-renewal of breast cancer stem cells via mutually exclusive splicing of PKM pre-mRNA.
Authors: Lv X; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Pharmaceutical Experiment Teaching Center, School of Pharmacy, China Medical University, Shenyang, China., Han L; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Tong WW; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China., Sun X; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Xu S; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Yan Y; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Zhou S; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Zhang Y; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Zhang D; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Wang J; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Liu J; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Zhao H; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Yao W; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Xiao R; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Wang Q; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Xu J; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Gong L; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China., Wei M; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China. mjwei@cmu.eud.cn.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China. mjwei@cmu.eud.cn.; Liaoning Medical Diagnosis and Treatment Center, Shenyang, China. mjwei@cmu.eud.cn., Chen B; Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, China. bochen@cmu.edu.cn., He M; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China. hemiao_cmu@126.com.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China. hemiao_cmu@126.com.
Source: Oncogene [Oncogene] 2026 Jun; Vol. 45 (20), pp. 1914-1929. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Blocking ubiquitination of hnRNPA1 maintains the self-renewal of breast cancer stem cells via mutually exclusive splicing of PKM pre-mRNA.
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  Data: <searchLink fieldCode="AU" term="%22Lv+X%22">Lv X</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Pharmaceutical Experiment Teaching Center, School of Pharmacy, China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Han+L%22">Han L</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Tong+WW%22">Tong WW</searchLink>; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+S%22">Zhou S</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Yao+W%22">Yao W</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Xiao+R%22">Xiao R</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Gong+L%22">Gong L</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Wei+M%22">Wei M</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China. mjwei@cmu.eud.cn.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China. mjwei@cmu.eud.cn.; Liaoning Medical Diagnosis and Treatment Center, Shenyang, China. mjwei@cmu.eud.cn.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, China. bochen@cmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China. hemiao_cmu@126.com.; Liaoning Key Laboratory of molecular targeted antitumor drug development and evaluation, Shenyang, China. hemiao_cmu@126.com.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Jun; Vol. 45 (20), pp. 1914-1929. <i>Date of Electronic Publication: </i>2026 Apr 14.
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              Text: 2026 Jun
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