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Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity.

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Title: Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity.
Authors: Nicola PA; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Lawson ARJ; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK. al28@sanger.ac.uk., Tidd A; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Imbert J; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Ishida Y; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Wylie LA; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Scott PA; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Roberts K; Cellular Operations, Wellcome Sanger Institute, Hinxton, UK., Harvey LMR; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Lensing SV; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Cheng W; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Abascal F; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Leongamornlert D; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Hooks Y; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Mayho M; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Müller-Sienerth N; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Widaa S; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Mincarelli L; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Illing J; Cytometry Core Facility, Wellcome Sanger Institute, Hinxton, UK., Peci F; Cytometry Core Facility, Wellcome Sanger Institute, Hinxton, UK., Ng BL; Cytometry Core Facility, Wellcome Sanger Institute, Hinxton, UK., Jarman GL; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Russell AJC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Mahbubani KTA; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Paterson AL; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Chatterjee K; Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK., Rahbari R; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Bayraktar OA; Cellular Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Stratton MR; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK., Campbell PJ; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.; Quotient Therapeutics Limited, Saffron Walden, UK., Tadross JA; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; Cambridge Genomics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Schoenmakers N; Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Martincorena I; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8117), pp. 131-141. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nicola+PA%22">Nicola PA</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Lawson+ARJ%22">Lawson ARJ</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK. al28@sanger.ac.uk.<br /><searchLink fieldCode="AU" term="%22Tidd+A%22">Tidd A</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Imbert+J%22">Imbert J</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Ishida+Y%22">Ishida Y</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Wylie+LA%22">Wylie LA</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Scott+PA%22">Scott PA</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+K%22">Roberts K</searchLink>; Cellular Operations, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Harvey+LMR%22">Harvey LMR</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Lensing+SV%22">Lensing SV</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Cheng+W%22">Cheng W</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Abascal+F%22">Abascal F</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Leongamornlert+D%22">Leongamornlert D</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Hooks+Y%22">Hooks Y</searchLink>; 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Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rahbari+R%22">Rahbari R</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Bayraktar+OA%22">Bayraktar OA</searchLink>; Cellular Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Stratton+MR%22">Stratton MR</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK.; Quotient Therapeutics Limited, Saffron Walden, UK.<br /><searchLink fieldCode="AU" term="%22Tadross+JA%22">Tadross JA</searchLink>; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; Cambridge Genomics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Schoenmakers+N%22">Schoenmakers N</searchLink>; Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Martincorena+I%22">Martincorena I</searchLink>; Somatic Genomics Programme, Wellcome Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.
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