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Midkine as a novel prognostic and therapeutic target in meningioma: insights from single-cell analysis and organoid-based drug validation.

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Title: Midkine as a novel prognostic and therapeutic target in meningioma: insights from single-cell analysis and organoid-based drug validation.
Authors: Li PR; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Chen FY; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Song LR; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Zhang JT; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Wu Z; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China., Chen W; Key Laboratory of Biomechanics and Mechanobiology , (Beihang University) Ministry of Education, Beijing, China. chenw123@buaa.edu.cn.; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, Beijing, China. chenw123@buaa.edu.cn.; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beijing, China. chenw123@buaa.edu.cn.; School of Biological Science and Medical Engineering, Beihang University, Beijing, China. chenw123@buaa.edu.cn., Wang L; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. saintage7@126.com.; China National Clinical Research Center for Neurological Diseases, Beijing, China. saintage7@126.com.; Department of Neurosurgery, Ningxia Hui Autonomous Region People's Hospital, Ningxia, China. saintage7@126.com.
Source: Journal of translational medicine [J Transl Med] 2026 Apr 14; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Midkine as a novel prognostic and therapeutic target in meningioma: insights from single-cell analysis and organoid-based drug validation.
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  Data: <searchLink fieldCode="AU" term="%22Li+PR%22">Li PR</searchLink>; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+FY%22">Chen FY</searchLink>; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Song+LR%22">Song LR</searchLink>; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+JT%22">Zhang JT</searchLink>; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Key Laboratory of Biomechanics and Mechanobiology , (Beihang University) Ministry of Education, Beijing, China. chenw123@buaa.edu.cn.; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, Beijing, China. chenw123@buaa.edu.cn.; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beijing, China. chenw123@buaa.edu.cn.; School of Biological Science and Medical Engineering, Beihang University, Beijing, China. chenw123@buaa.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. saintage7@126.com.; China National Clinical Research Center for Neurological Diseases, Beijing, China. saintage7@126.com.; Department of Neurosurgery, Ningxia Hui Autonomous Region People's Hospital, Ningxia, China. saintage7@126.com.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Apr 14; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Apr 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08068-3
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        Text: English
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      – TitleFull: Midkine as a novel prognostic and therapeutic target in meningioma: insights from single-cell analysis and organoid-based drug validation.
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            – D: 14
              M: 04
              Text: 2026 Apr 14
              Type: published
              Y: 2026
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