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Losartan to Improve Outcomes after multi-ligament kNee injury (LION Trial).

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Title: Losartan to Improve Outcomes after multi-ligament kNee injury (LION Trial).
Authors: Kehoe S; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA., Stone A; University of Kentucky, Lexington, USA., Yuan X; Walter Reed National Military Medical Center, Bethesda, USA.; Uniformed Services University of the Health Sciences, Bethesda, USA., Conley C; University of Kentucky, Lexington, USA., Hawk G; University of Kentucky, Lexington, USA., Smith S; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Zgoda M; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA., Corey N; University of Kentucky, Lexington, USA., Johnson D; University of Kentucky, Lexington, USA., Wilson B; University of Kentucky, Lexington, USA., Zhou L; Walter Reed National Military Medical Center, Bethesda, USA., Berkson E; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Goertz S; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Huff L; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Hutchinson I; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Matzkin E; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Richardson L; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Lattermann C; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA., Jacobs C; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA. cjacobs@bwh.harvard.edu.; Harvard Medical School, Boston, USA. cjacobs@bwh.harvard.edu.
Source: Trials [Trials] 2026 Apr 14; Vol. 27 (1). Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Losartan to Improve Outcomes after multi-ligament kNee injury (LION Trial).
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  Data: <searchLink fieldCode="AU" term="%22Kehoe+S%22">Kehoe S</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.<br /><searchLink fieldCode="AU" term="%22Stone+A%22">Stone A</searchLink>; University of Kentucky, Lexington, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+X%22">Yuan X</searchLink>; Walter Reed National Military Medical Center, Bethesda, USA.; Uniformed Services University of the Health Sciences, Bethesda, USA.<br /><searchLink fieldCode="AU" term="%22Conley+C%22">Conley C</searchLink>; University of Kentucky, Lexington, USA.<br /><searchLink fieldCode="AU" term="%22Hawk+G%22">Hawk G</searchLink>; University of Kentucky, Lexington, USA.<br /><searchLink fieldCode="AU" term="%22Smith+S%22">Smith S</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Zgoda+M%22">Zgoda M</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.<br /><searchLink fieldCode="AU" term="%22Corey+N%22">Corey N</searchLink>; University of Kentucky, Lexington, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+D%22">Johnson D</searchLink>; University of Kentucky, Lexington, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+B%22">Wilson B</searchLink>; University of Kentucky, Lexington, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Walter Reed National Military Medical Center, Bethesda, USA.<br /><searchLink fieldCode="AU" term="%22Berkson+E%22">Berkson E</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Goertz+S%22">Goertz S</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Huff+L%22">Huff L</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Hutchinson+I%22">Hutchinson I</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Matzkin+E%22">Matzkin E</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+L%22">Richardson L</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Lattermann+C%22">Lattermann C</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA.; Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+C%22">Jacobs C</searchLink>; Mass General Brigham, 20 Patriot Pl, 3Rd Floor, Foxborough, MA, 02035, USA. cjacobs@bwh.harvard.edu.; Harvard Medical School, Boston, USA. cjacobs@bwh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Apr 14; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Apr 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13063-026-09714-3
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        Text: English
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              Text: 2026 Apr 14
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