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Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis.

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Title: Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis.
Authors: Sims GP; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Scaletta L; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Andrews J; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Sims DA; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Strain M; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Sigurdardottir A; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Kuriakose T; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., England E; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Rajasinghe L; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Jiang F; Translational Science and Experimental Medicine, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Xiong X; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Neal F; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Vinall L; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Newton P; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Boger E; DMPK, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Kim C; Integrated Bioanalysis, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, United Sates of America., Dahlbäck H; DMPK, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Prothon S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Leander J; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Darrah E; Translational Science and Experimental Medicine, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Collins M; Translational Science and Experimental Medicine, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Douglas G; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., White N; Integrated Bioanalysis, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Day K; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vousden KA; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Huntington CE; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK., Close D; Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Source: MAbs [MAbs] 2026 Dec; Vol. 18 (1), pp. 2657629. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE
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  Data: Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis.
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  Data: <searchLink fieldCode="AU" term="%22Sims+GP%22">Sims GP</searchLink>; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA.<br /><searchLink fieldCode="AU" term="%22Scaletta+L%22">Scaletta L</searchLink>; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA.<br /><searchLink fieldCode="AU" term="%22Andrews+J%22">Andrews J</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sims+DA%22">Sims DA</searchLink>; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA.<br /><searchLink fieldCode="AU" term="%22Strain+M%22">Strain M</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sigurdardottir+A%22">Sigurdardottir A</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kuriakose+T%22">Kuriakose T</searchLink>; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA.<br /><searchLink fieldCode="AU" term="%22England+E%22">England E</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rajasinghe+L%22">Rajasinghe L</searchLink>; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+F%22">Jiang F</searchLink>; Translational Science and Experimental Medicine, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Xiong+X%22">Xiong X</searchLink>; Immunology Biosciences, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA.<br /><searchLink fieldCode="AU" term="%22Neal+F%22">Neal F</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vinall+L%22">Vinall L</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Newton+P%22">Newton P</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Boger+E%22">Boger E</searchLink>; DMPK, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Kim+C%22">Kim C</searchLink>; Integrated Bioanalysis, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, United Sates of America.<br /><searchLink fieldCode="AU" term="%22Dahlbäck+H%22">Dahlbäck H</searchLink>; DMPK, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Prothon+S%22">Prothon S</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Leander+J%22">Leander J</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Darrah+E%22">Darrah E</searchLink>; Translational Science and Experimental Medicine, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA.<br /><searchLink fieldCode="AU" term="%22Collins+M%22">Collins M</searchLink>; Translational Science and Experimental Medicine, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Douglas+G%22">Douglas G</searchLink>; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22White+N%22">White N</searchLink>; Integrated Bioanalysis, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Day+K%22">Day K</searchLink>; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vousden+KA%22">Vousden KA</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Huntington+CE%22">Huntington CE</searchLink>; R&D, Biologics Engineering, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Close+D%22">Close D</searchLink>; Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
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