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Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.

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Title: Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.
Authors: Mix MR; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine., Sievers CM; Department of Pathology, Carver College of Medicine., Hassert M; Department of Pathology, Carver College of Medicine., Kannan SK; Department of Pathology, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Holden Comprehensive Cancer Center, Carver College of Medicine., Pewe LL; Department of Pathology, Carver College of Medicine., Huang SC; Holden Comprehensive Cancer Center, Carver College of Medicine.; Free Radical and Radiation Biology Training Program, Department of Radiation Oncology, Carver College of Medicine., He R; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy., Fain CE; Department of Pathology, Carver College of Medicine., Heidarian M; Department of Pathology, Carver College of Medicine.; Holden Comprehensive Cancer Center, Carver College of Medicine.; Experimental Pathology Graduate Program, Carver College of Medicine, and., Hancox LS; Department of Pathology, Carver College of Medicine., Arumugam SA; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine., Beltz TG; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Jin F; Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA., Johnson AJ; Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA., Carter CS; Holden Comprehensive Cancer Center, Carver College of Medicine.; Free Radical and Radiation Biology Training Program, Department of Radiation Oncology, Carver College of Medicine.; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Butler NS; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Salem AK; Holden Comprehensive Cancer Center, Carver College of Medicine.; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy., Badovinac VP; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Holden Comprehensive Cancer Center, Carver College of Medicine.; Experimental Pathology Graduate Program, Carver College of Medicine, and., Harty JT; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Experimental Pathology Graduate Program, Carver College of Medicine, and.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Apr 15; Vol. 136 (8). Date of Electronic Publication: 2026 Apr 15 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.
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  Data: <searchLink fieldCode="AU" term="%22Mix+MR%22">Mix MR</searchLink>; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Sievers+CM%22">Sievers CM</searchLink>; Department of Pathology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Hassert+M%22">Hassert M</searchLink>; Department of Pathology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Kannan+SK%22">Kannan SK</searchLink>; Department of Pathology, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Holden Comprehensive Cancer Center, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Pewe+LL%22">Pewe LL</searchLink>; Department of Pathology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Huang+SC%22">Huang SC</searchLink>; Holden Comprehensive Cancer Center, Carver College of Medicine.; Free Radical and Radiation Biology Training Program, Department of Radiation Oncology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22He+R%22">He R</searchLink>; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy.<br /><searchLink fieldCode="AU" term="%22Fain+CE%22">Fain CE</searchLink>; Department of Pathology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Heidarian+M%22">Heidarian M</searchLink>; Department of Pathology, Carver College of Medicine.; Holden Comprehensive Cancer Center, Carver College of Medicine.; Experimental Pathology Graduate Program, Carver College of Medicine, and.<br /><searchLink fieldCode="AU" term="%22Hancox+LS%22">Hancox LS</searchLink>; Department of Pathology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Arumugam+SA%22">Arumugam SA</searchLink>; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.<br /><searchLink fieldCode="AU" term="%22Beltz+TG%22">Beltz TG</searchLink>; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Jin+F%22">Jin F</searchLink>; Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+AJ%22">Johnson AJ</searchLink>; Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Carter+CS%22">Carter CS</searchLink>; Holden Comprehensive Cancer Center, Carver College of Medicine.; Free Radical and Radiation Biology Training Program, Department of Radiation Oncology, Carver College of Medicine.; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Butler+NS%22">Butler NS</searchLink>; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Salem+AK%22">Salem AK</searchLink>; Holden Comprehensive Cancer Center, Carver College of Medicine.; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy.<br /><searchLink fieldCode="AU" term="%22Badovinac+VP%22">Badovinac VP</searchLink>; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Holden Comprehensive Cancer Center, Carver College of Medicine.; Experimental Pathology Graduate Program, Carver College of Medicine, and.<br /><searchLink fieldCode="AU" term="%22Harty+JT%22">Harty JT</searchLink>; Department of Pathology, Carver College of Medicine.; Medical Scientist Training Program, Carver College of Medicine.; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine.; Experimental Pathology Graduate Program, Carver College of Medicine, and.
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