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In vitro mechanistic study of human CYP2B6-catalyzed bioactivation and GSTs-mediated detoxification of chlorfenapyr.

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Title: In vitro mechanistic study of human CYP2B6-catalyzed bioactivation and GSTs-mediated detoxification of chlorfenapyr.
Authors: Deng L; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Yan H; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Qian Z; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Zhong J; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Xie W; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Wang J; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China., Xu J; Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China., Gao H; Emergency Department, Qujing Central Hospital of Yunnan Province, Affiliated Qujing Hospital of Kunming Medical University, Qujing, 655000, China., Zong L; Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China., Chen X; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. chenxj-lab@hotmail.com., Huang H; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. haoyan@cpu.edu.cn., Zhang Y; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. zhangyongjie@cpu.edu.cn.
Source: Archives of toxicology [Arch Toxicol] 2026 Jul; Vol. 100 (7), pp. 2941-2953. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vitro mechanistic study of human CYP2B6-catalyzed bioactivation and GSTs-mediated detoxification of chlorfenapyr.
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  Data: <searchLink fieldCode="AU" term="%22Deng+L%22">Deng L</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Yan+H%22">Yan H</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Qian+Z%22">Qian Z</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Zhong+J%22">Zhong J</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Xie+W%22">Xie W</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Emergency Department, Qujing Central Hospital of Yunnan Province, Affiliated Qujing Hospital of Kunming Medical University, Qujing, 655000, China.<br /><searchLink fieldCode="AU" term="%22Zong+L%22">Zong L</searchLink>; Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. chenxj-lab@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. haoyan@cpu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. zhangyongjie@cpu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Jul; Vol. 100 (7), pp. 2941-2953. <i>Date of Electronic Publication: </i>2026 Apr 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0417615 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0738 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405761%22">03405761 </searchLink><i>NLM ISO Abbreviation: </i>Arch Toxicol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00204-026-04390-3
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              Text: 2026 Jul
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              Y: 2026
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