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Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review.

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Title: Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review.
Authors: Orsini DK; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Wong S; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Di Luch S; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Chan B; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada., Vasudeva S; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada., Lovell GFM; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Le GH; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Jones BDM; Department of Psychiatry, University of Toronto, Toronto, Canada.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Chisamore N; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Mollica A; Department of Psychiatry, University of Toronto, Toronto, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada., Johnson DE; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Kaczmarek ES; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Goel A; Department of Anesthesiology & Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia and Pain Medicine, St Michael's Hospital, Toronto, Ontario, Canada., Burke MJ; Department of Psychiatry, University of Toronto, Toronto, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Psychiatry, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada., Mansur R; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada., McIntyre RS; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada., Husain MI; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada., Rosenblat JD; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.
Source: JAMA psychiatry [JAMA Psychiatry] 2026 Jul 01; Vol. 83 (7), pp. 755-769.
Publication Type: Systematic Review; Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589550 Publication Model: Print Cited Medium: Internet ISSN: 2168-6238 (Electronic) Linking ISSN: 2168622X NLM ISO Abbreviation: JAMA Psychiatry Subsets: MEDLINE
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Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Vasudeva+S%22">Vasudeva S</searchLink>; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Lovell+GFM%22">Lovell GFM</searchLink>; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Le+GH%22">Le GH</searchLink>; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Jones+BDM%22">Jones BDM</searchLink>; 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Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Goel+A%22">Goel A</searchLink>; Department of Anesthesiology & Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia and Pain Medicine, St Michael's Hospital, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Burke+MJ%22">Burke MJ</searchLink>; Department of Psychiatry, University of Toronto, Toronto, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Psychiatry, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mansur+R%22">Mansur R</searchLink>; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22McIntyre+RS%22">McIntyre RS</searchLink>; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Husain+MI%22">Husain MI</searchLink>; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Canada.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rosenblat+JD%22">Rosenblat JD</searchLink>; Poul Hansen Family Centre for Depression, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; 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