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Myocardial Fibrosis and Early Intervention in Asymptomatic Patients With Severe Aortic Stenosis: Insights From the EVOLVED Randomized Clinical Trial.

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Title: Myocardial Fibrosis and Early Intervention in Asymptomatic Patients With Severe Aortic Stenosis: Insights From the EVOLVED Randomized Clinical Trial.
Authors: Craig NJ; British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland.; Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland., Loganath K; British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland., Everett RJ; Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland., Bing R; Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland., Ramtoola T; British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland.; Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland., Tsampasian V; Norwich Medical School, University of East Anglia, United Kingdom.; Department of Cardiology, Norfolk and Norwich University Hospital, United Kingdom., Molek P; Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, Krakow, Poland., Botezatu S; University of Medicine and Pharmacy Carol Davila, Cardiology Department, Euroecholab, Bucharest, Romania., Aslam S; Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., MacGillivray T; Edinburgh Imaging, The University of Edinburgh, Edinburgh, Scotland., Tuck CE; British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland., Rayson P; Edinburgh Clinical Trials Unit, Usher Institute, The University of Edinburgh, Edinburgh, Scotland., Calvert PA; Royal Papworth Hospital NHS Foundation Trust, and University of Cambridge, Cambridge, United Kingdom., Berry C; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom., Chin CWL; Department of Cardiology, National Heart Centre Singapore, Singapore.; Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia., Hillis GS; Medical School, University of Western Australia, Perth, Western Australia, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Fairbairn T; Department of Cardiology, Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom., Greenwood JP; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom., Steeds R; Department of Cardiology, Queen Elizabeth Hospital Birmingham, University Hospitals of Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Leslie SJ; Cardiac Unit, Raigmore Hospital, Inverness, Scotland., Lang CC; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, United Kingdom.; Tuanku Muhriz Chair, National University of Malaysia, Malaysia., Bucciarelli-Ducci C; Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, United Kingdom.; Royal Brompton and Harefield Hospitals, Guys' and St Thomas NHS Foundation Trust, London, United Kingdom., Joshi NV; Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, United Kingdom., Kunadian V; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle.; University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Prendergast B; Cleveland Clinic London and St Thomas' Hospital, London, United Kingdom., Mills NL; British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland.; Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland.; Usher Institute, The University of Edinburgh, Edinburgh, Scotland., Vassiliou VS; Norwich Medical School, University of East Anglia, United Kingdom.; Department of Cardiology, Norfolk and Norwich University Hospital, United Kingdom., Dungu JN; Essex Cardiothoracic Centre, Nethermayne, Basildon, Essex, United Kingdom.; Anglia Ruskin University, Chelmsford, Essex, United Kingdom., Hothi SS; Department of Cardiology, Royal Wolverhampton NHS Trust, Wolverhampton, United Kingdom.; Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom., Boon N; Retired, Hertfordshire, United Kingdom., Prasad SK; Royal Brompton and Harefield Hospitals, Guys' and St Thomas NHS Foundation Trust, London, United Kingdom., Keenan NG; Department of Cardiology, West Hertfordshire Hospitals NHS Trust, Watford, United Kingdom.; Imperial College, London, United Kingdom., Dawson D; Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, Aberdeen, Scotland., Motwani M; Department of Cardiology, Manchester Heart Institute, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom., Miller CA; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom., Rajani R; Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Ripley DP; Cardiology, Northumbria Healthcare NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Treibel TA; Institute of Cardiovascular Sciences, University College London, and St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom., McCann GP; Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Singh A; Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Newby DE; British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland.; Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland., Dweck MR; British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland.; Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, Scotland.
Corporate Authors: EVOLVED investigators
Source: JAMA cardiology [JAMA Cardiol] 2026 Jun 01; Vol. 11 (6), pp. 599-605.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101676033 Publication Model: Print Cited Medium: Internet ISSN: 2380-6591 (Electronic) NLM ISO Abbreviation: JAMA Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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