Evaluation of therapeutic efficacy of baloxavir marboxil against high pathogenicity avian influenza virus infection in duck model.

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Title: Evaluation of therapeutic efficacy of baloxavir marboxil against high pathogenicity avian influenza virus infection in duck model.
Authors: Shimazu Y; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan., Isoda N; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Hokkaido, Japan., Hiono T; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Hokkaido, Japan., Hew YL; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan., Kobayashi D; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan., Shibazaki M; Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan., Nguyen BL; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan., Morita T; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan., Obara RD; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan., Miki M; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan., Osaki H; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan., Shishido T; Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan., Ikenaka Y; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; Laboratory of Toxicology, Department of Environmental Veterinary Science, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa., Sakoda Y; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Hokkaido, Japan.
Source: PloS one [PLoS One] 2026 Apr 15; Vol. 21 (4), pp. e0347205. Date of Electronic Publication: 2026 Apr 15 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
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  Data: Evaluation of therapeutic efficacy of baloxavir marboxil against high pathogenicity avian influenza virus infection in duck model.
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  Data: <searchLink fieldCode="AU" term="%22Shimazu+Y%22">Shimazu Y</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Isoda+N%22">Isoda N</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Hiono+T%22">Hiono T</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Hew+YL%22">Hew YL</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+D%22">Kobayashi D</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Shibazaki+M%22">Shibazaki M</searchLink>; Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nguyen+BL%22">Nguyen BL</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Morita+T%22">Morita T</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Obara+RD%22">Obara RD</searchLink>; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Miki+M%22">Miki M</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Osaki+H%22">Osaki H</searchLink>; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Shishido+T%22">Shishido T</searchLink>; Laboratory for Drug Discovery and Disease Research, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ikenaka+Y%22">Ikenaka Y</searchLink>; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; Laboratory of Toxicology, Department of Environmental Veterinary Science, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa.<br /><searchLink fieldCode="AU" term="%22Sakoda+Y%22">Sakoda Y</searchLink>; Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.; One Health Research Center, Hokkaido University, Sapporo, Hokkaido, Japan.; International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Hokkaido, Japan.
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