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The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors.

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Title: The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors.
Authors: Gonzalez-Rellan MJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada., Riobello C; Liver Metabolism and Disorders Laboratory, CIMUS University of Santiago de Compostela, A Coruña, Spain; Gene Regulatory Control in Disease, CIMUS University of Santiago de Compostela, A Coruña, Spain., Fang S; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada., Martins da Silva E; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada., Koehler JA; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada., Shang R; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada., Hammoud R; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada., Cao X; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada., Varela-Rey M; Liver Metabolism and Disorders Laboratory, CIMUS University of Santiago de Compostela, A Coruña, Spain; Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, A Coruña, Spain., Drucker DJ; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada. Electronic address: drucker@lunenfeld.ca.
Source: Cell metabolism [Cell Metab] 2026 Jul 07; Vol. 38 (7), pp. 1334-1353.e7. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors.
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  Data: <searchLink fieldCode="AU" term="%22Gonzalez-Rellan+MJ%22">Gonzalez-Rellan MJ</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Riobello+C%22">Riobello C</searchLink>; Liver Metabolism and Disorders Laboratory, CIMUS University of Santiago de Compostela, A Coruña, Spain; Gene Regulatory Control in Disease, CIMUS University of Santiago de Compostela, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Fang+S%22">Fang S</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Martins+da+Silva+E%22">Martins da Silva E</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Koehler+JA%22">Koehler JA</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Shang+R%22">Shang R</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hammoud+R%22">Hammoud R</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Varela-Rey+M%22">Varela-Rey M</searchLink>; Liver Metabolism and Disorders Laboratory, CIMUS University of Santiago de Compostela, A Coruña, Spain; Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Drucker+DJ%22">Drucker DJ</searchLink>; Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada. Electronic address: drucker@lunenfeld.ca.
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  Data: <searchLink fieldCode="JN" term="%22101233170%22">Cell metabolism</searchLink> [Cell Metab] 2026 Jul 07; Vol. 38 (7), pp. 1334-1353.e7. <i>Date of Electronic Publication: </i>2026 Apr 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101233170 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-7420 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215504131%22">15504131 </searchLink><i>NLM ISO Abbreviation: </i>Cell Metab <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.cmet.2026.03.011
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              Text: 2026 Jul 07
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