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CSF1R inhibitors mitigate CDK4/6 inhibitor-induced immunosuppression to increase antitumor immunity in HR+/HER2- breast cancer.

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Title: CSF1R inhibitors mitigate CDK4/6 inhibitor-induced immunosuppression to increase antitumor immunity in HR+/HER2- breast cancer.
Authors: Li S; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Gong Y; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Li H; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Liu S; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Yin Y; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Yu Y; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Chu Y; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Hou J; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Liu J; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Zhang H; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Nanding A; Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China., Yuan W; Institute of Cancer Prevention and Treatment, Harbin Medical University, Harbin, China.; Institute of Cancer Prevention and Treatment, Heilongjiang Academy of Medical Sciences, Harbin, China., Zhang Y; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China., Wang Q; Department of Scientific Research, Harbin Medical University Cancer Hospital, Harbin, China., Wu H; Sino-Russian Medical Research Center, Harbin Medical University Cancer Hospital, Harbin, China., Zhang X; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China. zhangxianyu@ems.hrbmu.edu.cn., Pang D; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China. pangda@ems.hrbmu.edu.cn.
Source: Oncogene [Oncogene] 2026 Jun; Vol. 45 (21), pp. 1970-1987. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CSF1R inhibitors mitigate CDK4/6 inhibitor-induced immunosuppression to increase antitumor immunity in HR+/HER2- breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Gong+Y%22">Gong Y</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yin+Y%22">Yin Y</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Chu+Y%22">Chu Y</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Nanding+A%22">Nanding A</searchLink>; Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yuan+W%22">Yuan W</searchLink>; Institute of Cancer Prevention and Treatment, Harbin Medical University, Harbin, China.; Institute of Cancer Prevention and Treatment, Heilongjiang Academy of Medical Sciences, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Scientific Research, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Sino-Russian Medical Research Center, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China. zhangxianyu@ems.hrbmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Pang+D%22">Pang D</searchLink>; Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China. pangda@ems.hrbmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Jun; Vol. 45 (21), pp. 1970-1987. <i>Date of Electronic Publication: </i>2026 Apr 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8711562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5594 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209509232%22">09509232 </searchLink><i>NLM ISO Abbreviation: </i>Oncogene <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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