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An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration.

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Title: An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration.
Authors: Honey MIJ; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Hok-A-Hin YS; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Thijssen EH; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Cousins KAQ; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., van der Weijden B; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., In 't Veld L; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Stoops E; ADx NeuroSciences, Ghent, Belgium., de Boer SCM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.; The University of Sydney, School of Psychology and Brain & Mind Centre, Sydney, New South Wales, Australia., Duits FH; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., de Houwer JFH; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Morrema THJ; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Alcolea D; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Illán-Gala I; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Fortea J; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Lleó A; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Boxer AL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Irwin DJ; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lee EB; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shaw L; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., McMillan CT; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wolk DA; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hoozemans JJM; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Nederland, Amersfoort, the Netherlands., van der Ende E; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Seelaar H; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Verberk IMW; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Gan L; Weill Cornell Medicine, Brain and Mind Research Institute, New York City, NY, USA., Pijnenburg Y; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands. c.teunissen@amsterdamumc.nl.
Source: Nature medicine [Nat Med] 2026 Jun; Vol. 32 (6), pp. 2083-2095. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Honey+MIJ%22">Honey MIJ</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hok-A-Hin+YS%22">Hok-A-Hin YS</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Thijssen+EH%22">Thijssen EH</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cousins+KAQ%22">Cousins KAQ</searchLink>; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22van+der+Weijden+B%22">van der Weijden B</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22In+'t+Veld+L%22">In 't Veld L</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Stoops+E%22">Stoops E</searchLink>; ADx NeuroSciences, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22de+Boer+SCM%22">de Boer SCM</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.; The University of Sydney, School of Psychology and Brain & Mind Centre, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Duits+FH%22">Duits FH</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Houwer+JFH%22">de Houwer JFH</searchLink>; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Morrema+THJ%22">Morrema THJ</searchLink>; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Alcolea+D%22">Alcolea D</searchLink>; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Illán-Gala+I%22">Illán-Gala I</searchLink>; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fortea+J%22">Fortea J</searchLink>; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lleó+A%22">Lleó A</searchLink>; Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Boxer+AL%22">Boxer AL</searchLink>; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Irwin+DJ%22">Irwin DJ</searchLink>; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+EB%22">Lee EB</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+L%22">Shaw L</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22McMillan+CT%22">McMillan CT</searchLink>; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wolk+DA%22">Wolk DA</searchLink>; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hoozemans+JJM%22">Hoozemans JJM</searchLink>; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Flier+WM%22">van der Flier WM</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Nederland, Amersfoort, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Ende+E%22">van der Ende E</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Seelaar+H%22">Seelaar H</searchLink>; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verberk+IMW%22">Verberk IMW</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gan+L%22">Gan L</searchLink>; Weill Cornell Medicine, Brain and Mind Research Institute, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pijnenburg+Y%22">Pijnenburg Y</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Teunissen+CE%22">Teunissen CE</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands. c.teunissen@amsterdamumc.nl.
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